Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Adiponectin Protects Against Paraquat-Induced Lung Injury By Attenuating Oxidative/Nitrative Stress., Rong Yao, Yaxiong Zhou, Yarong He, Yaowen Jiang, Peng Liu, Lei Ye, Zhijie Zheng, Wayne Bond Lau, Yu Cao, Zhi Zeng
Adiponectin Protects Against Paraquat-Induced Lung Injury By Attenuating Oxidative/Nitrative Stress., Rong Yao, Yaxiong Zhou, Yarong He, Yaowen Jiang, Peng Liu, Lei Ye, Zhijie Zheng, Wayne Bond Lau, Yu Cao, Zhi Zeng
Department of Emergency Medicine Faculty Papers
The specific mechanisms underlying paraquat (PQ)-induced lung injury remain unknown, which limits understanding of its cytotoxic potential. Although oxidative stress has been established as an important mechanism underlying PQ toxicity, multiple antioxidants have proven ineffective in attenuating the deleterious effects of PQ. Adiponectin, which shows anti-oxidative and antinitrative effects, may have the potential to reduce PQ-mediated injury. The present study determined the protective action of globular domain adiponectin (gAd) on PQ-induced lung injury, and attempted to elucidate the underlying mechanism or mechanisms of action. BALB/c mice were administered PQ, with and without 12 or 36 h of gAd pre-treatment. The …
Heme Oxygenase Activity And Hemoglobin Neurotoxicity Are Attenuated By Inhibitors Of The Mek/Erk Pathway., Jing Chen-Roetling, Zhi Li, Mai Chen, Olatilewa O. Awe, Raymond F. Regan
Heme Oxygenase Activity And Hemoglobin Neurotoxicity Are Attenuated By Inhibitors Of The Mek/Erk Pathway., Jing Chen-Roetling, Zhi Li, Mai Chen, Olatilewa O. Awe, Raymond F. Regan
Department of Emergency Medicine Faculty Papers
Hemoglobin breakdown produces an iron-dependent neuronal injury after experimental CNS hemorrhage that may be attenuated by heme oxygenase (HO) inhibitors. The HO enzymes are phosphoproteins that are activated by phosphorylation in vitro. While testing the effect of kinase inhibitors in cortical cell cultures, we observed that HO activity was consistently decreased by the MEK inhibitor U0126. The present study tested the hypothesis that MEK/ERK pathway inhibitors reduce HO activity and neuronal vulnerability to hemoglobin. The MEK inhibitors U0126 and SL327 and the ERK inhibitor FR180204 reduced baseline culture HO activity by 35-50%, without altering the activity of recombinant HO-1 or …