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Full-Text Articles in Medicine and Health Sciences
Obesity, Metabolic Factors And Risk Of Different Histological Types Of Lung Cancer: A Mendelian Randomization Study, Robert Carreras-Torres, Mattias Johansson, Philip C. Haycock, Kaitlin H. Wade, Caroline L. Relton, Richard M. Martin, George Davey Smith, Demetrius Albanes, Melinda C. Aldrich, Angeline Andrew, Susanne M. Arnold, Heike Bickeböller, Stig E. Bojesen, Hans Brunnstrom, Jonas Manjer, Irene Brüske, Neil E. Caporaso, Chu Chen, David C. Christiani, W. Jay Christian, Jennifer Doherty, Eric J. Duell, John K. Field, Michael P.A Davies, Michael W. Marcus, Gary E. Goodman, Kjell Grankvist, Aage Haugen, Yun-Chul Hong, Lambertus A. Kiemeney, Erik H.F.M Van Der Heijden, Peter Kraft, Mikael B. Johansson, Stephen Lam, Maria Teresa Landi, Philip Lazarus, Loic Le Marchand, Geoffrey Liu, Olle Melander, Sungshim L. Park, Gad Rennert, Angela Risch, Eric B. Haura, Ghislaine Scelo, David Zaridze, Anush Mukeriya, Milan Savić, Jolanta Lissowska, Beata Swiatkowska, Vladmir Janout, Ivana Holcatova, Dana Mates, Matthew B. Schabath, Hongbing Shen, Adonina Tardon, M. Dawn Teare, Penella Woll, Ming-Sound Tsao, Xifeng Wu, Jian-Min Yuan, Rayjean J. Hung, Christopher I. Amos, James Mckay, Paul Brennan
Obesity, Metabolic Factors And Risk Of Different Histological Types Of Lung Cancer: A Mendelian Randomization Study, Robert Carreras-Torres, Mattias Johansson, Philip C. Haycock, Kaitlin H. Wade, Caroline L. Relton, Richard M. Martin, George Davey Smith, Demetrius Albanes, Melinda C. Aldrich, Angeline Andrew, Susanne M. Arnold, Heike Bickeböller, Stig E. Bojesen, Hans Brunnstrom, Jonas Manjer, Irene Brüske, Neil E. Caporaso, Chu Chen, David C. Christiani, W. Jay Christian, Jennifer Doherty, Eric J. Duell, John K. Field, Michael P.A Davies, Michael W. Marcus, Gary E. Goodman, Kjell Grankvist, Aage Haugen, Yun-Chul Hong, Lambertus A. Kiemeney, Erik H.F.M Van Der Heijden, Peter Kraft, Mikael B. Johansson, Stephen Lam, Maria Teresa Landi, Philip Lazarus, Loic Le Marchand, Geoffrey Liu, Olle Melander, Sungshim L. Park, Gad Rennert, Angela Risch, Eric B. Haura, Ghislaine Scelo, David Zaridze, Anush Mukeriya, Milan Savić, Jolanta Lissowska, Beata Swiatkowska, Vladmir Janout, Ivana Holcatova, Dana Mates, Matthew B. Schabath, Hongbing Shen, Adonina Tardon, M. Dawn Teare, Penella Woll, Ming-Sound Tsao, Xifeng Wu, Jian-Min Yuan, Rayjean J. Hung, Christopher I. Amos, James Mckay, Paul Brennan
Dartmouth Scholarship
Background: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. Methods and findings: We identified genetic instruments for potential metabolic risk factors and evaluated these in relation to risk using 29,266 lung cancer cases (including 11,273 adenocarcinomas, 7,426 squamous cell and 2,664 small cell cases) and 56,450 controls. The MR risk analysis suggested a causal effect of body mass index (BMI) on lung cancer risk for two …
Production Of Putative Enhanced Oral Cholera Vaccine Strains That Express Toxin-Coregulated Pilus, Caitlyn A. Hauke, Ronald K. Taylor
Production Of Putative Enhanced Oral Cholera Vaccine Strains That Express Toxin-Coregulated Pilus, Caitlyn A. Hauke, Ronald K. Taylor
Dartmouth Scholarship
The use of whole cell killed (WCK) oral cholera vaccines is an important strategy for cholera prevention in endemic areas. To overcome current vaccine limitations, we engineered strains of V. cholerae to be non-toxigenic and to express the protective protein colonization factor, toxin-coregulated pilus (TCP), under scale-up conditions potentially amenable to vaccine production. Two V. cholerae clinical strains were selected and their cholera toxin genes deleted. The tcp operon was placed under control of a rhamnose-inducible promoter. Production and stability of TCP were assessed under various conditions. The strains lack detectable cholera toxin production. The addition of 0.1% …
Gene-Set Meta-Analysis Of Lung Cancer Identifies Pathway Related To Systemic Lupus Erythematosus, Albert Rosenberger, Melanie Sohns, Stefanie Friedrichs, Rayjean J. Hung, Gord Fehringer, John Mclaughlin, Christopher I. Amos, Paul Brennan, Angela Risch, Irene Bruske, Neil E. Caporaso, Maria Teresa Landi, David C. Christiani, Yongyue Wei, Heike Bickeboller
Gene-Set Meta-Analysis Of Lung Cancer Identifies Pathway Related To Systemic Lupus Erythematosus, Albert Rosenberger, Melanie Sohns, Stefanie Friedrichs, Rayjean J. Hung, Gord Fehringer, John Mclaughlin, Christopher I. Amos, Paul Brennan, Angela Risch, Irene Bruske, Neil E. Caporaso, Maria Teresa Landi, David C. Christiani, Yongyue Wei, Heike Bickeboller
Dartmouth Scholarship
Introduction: Gene-set analysis (GSA) is an approach using the results of single-marker genome-wide association studies when investigating pathways as a whole with respect to the genetic basis of a disease. Methods: We performed a meta-analysis of seven GSAs for lung cancer, applying the method META- GSA. Overall, the information taken from 11,365 cases and 22,505 controls from within the TRICL/ILCCO consortia was used to investigate a total of 234 pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Results: META-GSA reveals the systemic lupus erythematosus KEGG pathway hsa05322 , driven by the gene region 6p21-22, as also …
Boosting Of Hiv Envelope Cd4 Binding Site Antibodies With Long Variable Heavy Third Complementarity Determining Region In The Randomized Double Blind Rv305 Hiv-1 Vaccine Trial, David Easterhoff, M. Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman
Boosting Of Hiv Envelope Cd4 Binding Site Antibodies With Long Variable Heavy Third Complementarity Determining Region In The Randomized Double Blind Rv305 Hiv-1 Vaccine Trial, David Easterhoff, M. Anthony Moody, Daniela Fera, Hao Cheng, Margaret Ackerman
Dartmouth Scholarship
The canary pox vector and gp120 vaccine (ALVAC-HIV and AIDSVAX B/E gp120) in the RV144 HIV-1 vaccine trial conferred an estimated 31% vaccine efficacy. Although the vaccine Env AE.A244 gp120 is antigenic for the unmutated common ancestor of V1V2 broadly neutralizing antibody (bnAbs), no plasma bnAb activity was induced. The RV305 (NCT01435135) HIV-1 clinical trial was a placebo-controlled randomized double-blinded study that assessed the safety and efficacy of vaccine boosting on B cell repertoires. HIV-1- uninfected RV144 vaccine recipients were reimmunized 6–8 years later with AIDSVAX B/E gp120 alone, ALVAC-HIV alone, or a combination of ALVAC-HIV and AIDSVAX B/E gp120 …