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Evaluation Of The Seca Inhibitors As Novel Anti-Microbial Agents, Christina Cerovsky, Jinshan Jin, Hsiuchin Yang, Binghe Wang, Phang C. Tai

DISCOVERY: Georgia State Honors College Undergraduate Research Journal

The misuse of conventional antibiotics and natural selection of the infectious bacterial population has produced drug resistance. Thus, novel effective antibiotic compounds that treat bacterial infections resistant to available therapies are needed. SecA is an indispensable ATPase of the protein translocation machinery present in all bacteria. SecA is responsible for the secretion of many essential proteins, some toxins and virulence factors, and is essential for bacterial survival. SecA has no counterpart in mammalian cells, thus provides an ideal target for developing antimicrobial agents. SCA-13 (HO) is a pyrimidine analog derived from virtual screening; it exerts the ability to inhibit SecA …