Medicine and Health Sciences Commons^™

Autophagy And Apoptosis: Current Challenges Of Treatment And Drug Resistance In Multiple Myeloma., Omar S Al-Odat, Daniel A Guirguis, Nicole K Schmalbach, Gabriella Yao, Tulin Budak-Alpdogan, Subash C. Jonnalagadda, Manoj K Pandey

Cooper Medical School of Rowan University Faculty Scholarship

Over the past two decades, the natural history of multiple myeloma (MM) has evolved dramatically, owing primarily to novel agents targeting MM in the bone marrow microenvironment (BMM) pathways. However, the mechanisms of resistance acquisition remain a mystery and are poorly understood. Autophagy and apoptosis are tightly controlled processes and play a critical role in the cell growth, development, and survival of MM. Genetic instability and abnormalities are two hallmarks of MM. During MM progression, plasma malignant cells become genetically unstable and activate various signaling pathways, resulting in the overexpression of abnormal proteins that disrupt autophagy and apoptosis biological processes. …

Vitamin D3 Supplementation At 5000 Iu Daily For The Prevention Of Influenza-Like Illness In Healthcare Workers: A Pragmatic Randomized Clinical Trial., Noud Van Helmond, Tracy L Brobyn, Patrick J Lariccia, Teresa Cafaro, Krystal Hunter, Satyajeet Roy, Brigid Bandomer, Kevin Q Ng, Helen Goldstein, Ludmil V Mitrev, Alan Tsai, Denise Thwing, Mary Ann Maag, Myung K Chung

Cooper Medical School of Rowan University Faculty Scholarship

Vitamin D supplementation has been shown to reduce the incidence of acute respiratory infections in populations at risk. The COVID-19 pandemic has highlighted the importance of preventing viral infections in healthcare workers. The aim of this study was to assess the hypothesis that vitamin D3 supplementation at 5000 IU daily reduces influenza-like illness (ILI), including COVID-19, in healthcare workers. We conducted a prospective, controlled trial at a tertiary university hospital. A random group of healthcare workers was invited to receive 5000 IU daily vitamin D3 supplementation for nine months, while other random healthcare system workers served as controls. All healthcare …

Emerin Interacts With Histone Methyltransferases To Regulate Repressive Chromatin At The Nuclear Periphery., Nicholas Marano, James M. Holaska

Cooper Medical School of Rowan University Faculty Scholarship

X-Linked Emery-Dreifuss muscular dystrophy is caused by mutations in the gene encoding emerin. Emerin is an inner nuclear membrane protein important for repressive chromatin organization at the nuclear periphery. Myogenic differentiation is a tightly regulated process characterized by genomic reorganization leading to coordinated temporal expression of key transcription factors, including MyoD, Pax7, and Myf5. Emerin was shown to interact with repressive histone modification machinery, including HDAC3 and EZH2. Using emerin-null myogenic progenitor cells we established several EDMD-causing emerin mutant lines in the effort to understand how the functional interaction of emerin with HDAC3 regulates histone methyltransferase localization or function to …

Peer Reviewed Evaluation Of Registered End-Points Of Randomised Trials (The Pre-Report Study): A Stepped Wedge, Cluster-Randomised Trial., Christopher Jones, Amanda Adams, Benjamin S Misemer, Mark A Weaver, Sara Schroter, Hayat Khan, Benyamin Margolis, David L Schriger, Timothy F Platts-Mills

Cooper Medical School of Rowan University Faculty Scholarship

OBJECTIVE: To test whether providing relevant clinical trial registry information to peer reviewers evaluating trial manuscripts decreases discrepancies between registered and published trial outcomes.

DESIGN: Stepped wedge, cluster-randomised trial, with clusters comprised of eligible manuscripts submitted to each participating journal between 1 November 2018 and 31 October 2019.

SETTING: Thirteen medical journals.

PARTICIPANTS: Manuscripts were eligible for inclusion if they were submitted to a participating journal during the study period, presented results from the primary analysis of a clinical trial, and were peer reviewed.

INTERVENTIONS: During the control phase, there were no changes to pre-existing peer review practices. After journals …

Protein S-Acylation As A New Paradigm In Cell Signaling, Darren Boehning

Cooper Medical School of Rowan University Faculty Scholarship

No abstract provided.

Marijuana For Parkinson's Disease, Gonzalo Carrasco

Cooper Medical School of Rowan University Faculty Scholarship

No abstract provided.

Effects Of Milkfat On The Gut Microbiome Of Patients After Bariatric Surgery, Sangita Phadtare

Cooper Medical School of Rowan University Faculty Scholarship

No abstract provided.