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Full-Text Articles in Medicine and Health Sciences
Co-Phosphorylation Networks Reveal Subtype-Specific Signaling Modules In Breast Cancer, Marzieh Ayati, Mark R. Chance, Mehmet Koyuturk
Co-Phosphorylation Networks Reveal Subtype-Specific Signaling Modules In Breast Cancer, Marzieh Ayati, Mark R. Chance, Mehmet Koyuturk
Computer Science Faculty Publications and Presentations
Motivation Protein phosphorylation is a ubiquitous mechanism of post-ranslational modification that plays a central role in cellular signaling. Phosphorylation is particularly important in the context of cancer, as down-regulation of tumor suppressors and up-regulation of oncogenes by the dysregulation of associated kinase and phosphatase networks are shown to have key roles in tumor growth and progression. Despite recent advances that enable large-scale monitoring of protein phosphorylation, these data are not fully incorporated into such computational tasks as phenotyping and subtyping of cancers.
Results We develop a network-based algorithm, CoPPNet, to enable unsupervised subtyping of cancers using phosphorylation data. For this …