Medicine and Health Sciences Commons^™

Neural Correlates Of Syntactic Comprehension: A Longitudinal Study, Shannon M. Sheppard, Erin L. Meier, Kevin T. Kim, Bonnie L. Breining, Lynsey M. Keator, Bohao Tang, Brian Caffo, Argye E. Hillis

Communication Sciences and Disorders Faculty Articles and Research

Broca’s area is frequently implicated in sentence comprehension but its specific role is debated. Most lesion studies have investigated deficits at the chronic stage. We aimed (1) to use acute imaging to predict which left hemisphere stroke patients will recover sentence comprehension; and (2) to better understand the role of Broca’s area in sentence comprehension by investigating acute deficits prior to functional reorganization. We assessed comprehension of canonical and noncanonical sentences in 15 patients with left hemisphere stroke at acute and chronic stages. LASSO regression was used to conduct lesion symptom mapping analyses. Patients with more severe word-level comprehension deficits …