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Behçet's Disease-A Literature Review, Poramate Pitak-Arnnop

Chulalongkorn University Dental Journal

Behçet's disease is a multisystemic inflammatory disease with histological evidence for vasculitis and characterized by mucocutaneous, ocular, articular, vascular, intestinal, pulmonary, renal and neurologic involvement. According to the diagnostic criteria formed by the International Study Group, recurrent oral ulceration is a prerequisite, with two more typical symptoms or signs. It is a disease of young adults with a more severe course in male subjects. Its prevalence is high in the Mediterranean basin, Turkey, Japan and those ethnic groups along the old Silk Route and has been known to be associated with HLA-B5 and HLA-B11. Although the pathogenesis of the disease …