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Antidepressant And Anti-Inflammatory Effects Of A Combined Fluoxetine And Celecoxib Treatment In A Rat Model Of Depression, Petcharat Trongtorsak, Wanida Olankijanunt, Angkawipa Trongtorsak, Uraiwan Intamaso
Antidepressant And Anti-Inflammatory Effects Of A Combined Fluoxetine And Celecoxib Treatment In A Rat Model Of Depression, Petcharat Trongtorsak, Wanida Olankijanunt, Angkawipa Trongtorsak, Uraiwan Intamaso
Chulalongkorn Medical Journal
Background : An evidence suggests a potential therapeutic target of depressiontoward treating inflammation with nonsteroidal anti-inflammatory drugs(NSAIDs). However, the efficacy of the combined standard antidepressantwith NSAID treatment still remains uncertain.Objective : To examine the effects of fluoxetine (serotonin reuptake inhibitor) inadjunct with celecoxib (specific COX-2 inhibitor) on depression-likebehavior and inflammation in rats with chronic mild stress (CMS) induceddepression.Methods : The rats were divided into 4 groups: control, CMS, CMS with fluoxetinetreatment (5 mg/kg/d), and CMS with fluoxetine and celecoxib treatment(5 mg/kg/d each). All treatments were continued for 5 weeks. Thedepression-like behavior was examined using forced swimming test.Blood samples were collected …