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Biostatistics and Epidemiology Faculty Publications Series

2021

Prevention

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Full-Text Articles in Medicine and Health Sciences

Uptake And Outcomes Of A Novel Community-Based Hiv Post-Exposure Prophylaxis (Pep) Programme In Rural Kenya And Uganda, James Ayieko, Maya L. Petersen, Jane Kabami, Florence Mwangwa, Fred Opel, Marilyn Nyabuti, Edwin D. Charlebois, James Peng, Catherine A. Koss, Laura B. Balzer Jan 2021

Uptake And Outcomes Of A Novel Community-Based Hiv Post-Exposure Prophylaxis (Pep) Programme In Rural Kenya And Uganda, James Ayieko, Maya L. Petersen, Jane Kabami, Florence Mwangwa, Fred Opel, Marilyn Nyabuti, Edwin D. Charlebois, James Peng, Catherine A. Koss, Laura B. Balzer

Biostatistics and Epidemiology Faculty Publications Series

Introduction Antiretroviral-based HIV prevention, including pre-exposure prophylaxis (PrEP), is expanding in generalized epidemic settings, but additional prevention options are needed for individuals with periodic, high-risk sexual exposures. Non-occupational post-exposure prophylaxis (PEP) is recommended in global guidelines. However, in Africa, awareness of and access to PEP for sexual exposures are limited. We assessed feasibility, acceptability, uptake and adherence in a pilot study of a patient-centred PEP programme with options for facility- or community-based service delivery. Methods After population-level HIV testing with universal access to PrEP for persons at elevated HIV risk (SEARCH Trial:NCT01864603), we conducted a pilot PEP study in five …