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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Impact Of Noise On Molecular Network Inference, Radhakrishnan Nagarajan, Marco Scutari
Impact Of Noise On Molecular Network Inference, Radhakrishnan Nagarajan, Marco Scutari
Biostatistics Faculty Publications
Molecular entities work in concert as a system and mediate phenotypic outcomes and disease states. There has been recent interest in modelling the associations between molecular entities from their observed expression profiles as networks using a battery of algorithms. These networks have proven to be useful abstractions of the underlying pathways and signalling mechanisms. Noise is ubiquitous in molecular data and can have a pronounced effect on the inferred network. Noise can be an outcome of several factors including: inherent stochastic mechanisms at the molecular level, variation in the abundance of molecules, heterogeneity, sensitivity of the biological assay or measurement …
Revealing The Ubiquitous Effects Of Quantum Entanglement-Toward A Notion Of God Logic, Wen-Ran Zhang, Karl E. Peace
Revealing The Ubiquitous Effects Of Quantum Entanglement-Toward A Notion Of God Logic, Wen-Ran Zhang, Karl E. Peace
Biostatistics Faculty Publications
Following Spinoza-Einstein’s interpretation of God or nature, the notion “God Logic” is proposed. This notion is to serve as an elicitation for a consistent set of necessary criteria for: 1) developing the logical foundation of quantum gravity as envisaged by Einstein, 2) revealing the ubiquitous effects of quantum entanglement as suggested by Roger Penrose, and 3) programming the universe as proposed by Seth Lloyd. An evolving set of eleven criteria is proposed for the notion. The possibility of inventing such a logical system is analyzed. A supersymmetrical candidate logic of negative-positive energy dynamic equilibrium is introduced and assessed against the …
Analysis Of Subgroup Data Of Clinical Trials, Kao-Tai Tsai, Karl E. Peace
Analysis Of Subgroup Data Of Clinical Trials, Kao-Tai Tsai, Karl E. Peace
Biostatistics Faculty Publications
Large randomized controlled clinical trials are the gold standard to evaluate and compare the effects of treatments. It is common practice for investigators to explore and even attempt to compare treatments, beyond the first round of primary analyses, for various subsets of the study populations based on scientific or clinical interests to take advantage of the potentially rich information contained in the clinical database. Although subjects are randomized to treatment groups in clinical trials, this does not imply the same degree of randomization among sub-populations of the original trials. Therefore, comparisons of treatments in sub-populations may not produce fair and …
Daily Walking And Life Expectancy Of Elderly People In The Iowa 65+ Rural Health Study, Hani M. Samawi
Daily Walking And Life Expectancy Of Elderly People In The Iowa 65+ Rural Health Study, Hani M. Samawi
Biostatistics Faculty Publications
The purpose of this paper is to investigate the hypothesis that outdoor daily walking, as an exercise, has an effect on the rate of mortality among those elderly people in the Iowa 65+ Rural Health Study (RHS). RHS is a prospective longitudinal cohort study of 8 years follow-up from 1981 to 1989. It consists of a random sample of 3,673 individuals (1,420 men and 2,253 women) aged 65 or older living in Washington and Iowa counties of the State of Iowa. Our analysis was conducted only on those non-institutional individuals who could without any help walk across a small room; …