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Full-Text Articles in Medicine and Health Sciences
Chronic Stress Prevents Cortico-Accumbens Cue Encoding And Alters Conditioned Approach, Mitchell Spring, Aaron Caccamise, Elizabeth A. Panther, Bethany M. Windsor, Karan R. Soni, Jayme R. Mcreynolds, Daniel S. Wheeler, John R. Mantsch, Robert A. Wheeler
Chronic Stress Prevents Cortico-Accumbens Cue Encoding And Alters Conditioned Approach, Mitchell Spring, Aaron Caccamise, Elizabeth A. Panther, Bethany M. Windsor, Karan R. Soni, Jayme R. Mcreynolds, Daniel S. Wheeler, John R. Mantsch, Robert A. Wheeler
Biomedical Sciences Faculty Research and Publications
Chronic stress impairs the function of multiple brain regions and causes severe hedonic and motivational deficits. One brain region known to be susceptible to these effects is the PFC. Neurons in this region, specifically neuronal projections from the prelimbic region (PL) to the nucleus accumbens core (NAcC), have a significant role in promoting motivated approach. However, little is known about how activity in this pathway changes during associative learning to encode cues that promote approach. Less is known about how activity in this pathway may be altered by stress. In this study, an intersectional fiber photometry approach was used in …