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Evaluation Of Fructosamine 3-Kinase And Glyoxalase 1 Activity In Normal And Breast Cancer Tissues, Tooba Yousefi, Abdol Rahim Gholizadeh Pasha, Ghodsieh Kamrani, Ailin Ebrahimzadeh, Ali Zahedian, Karimollah Hajian-Tilaki, Mohammad Aghajani, Durdi Qujeq

BioMedicine

Background: Breast cancer is a typical malignancy and the most common in the female and it is the primary reason behind cancer-related deaths of women around the world. The pathological role of the non-enzymatic change of proteins by reducing sugars become frequently shows in different kinds of cancer. Cancer cells generally rely upon aerobic glycolysis as the main source of energy. Impaired glucose metabolism is somewhat responsible for the aggregation of advanced glycation end products (AGEs). Methylglyoxal (MG), a glycolysis byproduct either contributes to the accumulation of AGEs. Enzymatic defense upon AGEs products exists in all mammalian cells. Aims: …