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Behavioral Changes In Aging But Not Young Mice After Neonatal Exposure To The Polybrominated Flame Retardant Decabde, Deborah C. Rice, W. Douglas Thompson, Elizabeth A. Reeve, Kristen D. Onos, Mina Assadollahzadeh, Vincent P. Markowski

Applied Medical Sciences [Discontinued]

BACKGROUND: After several decades of commercial use, the flame-retardant chemicals polybrominated diphenyl ethers (PBDEs) and their metabolites are pervasive environmental contaminants and are detected in the human body. Decabrominated diphenyl ether (decaBDE) is currently the only PBDE in production in the United States. OBJECTIVES: Little is known about the health effects of decaBDE. In the present study we examined the effects of neonatal decaBDE exposure on behavior in mice at two ages. METHODS: Neonatal male and female C57BL6/J mice were exposed to a daily oral dose of 0, 6, or 20 mg/kg decaBDE from postnatal days 2 through 15. Two …