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Natural Dietary Supplement, Carvacrol, Alleviates Lps-Induced Oxidative Stress, Neurodegeneration, And Depressive-Like Behaviors Via The Nrf2/Ho-1 Pathway, Komal Naeem, Lina Tariq Al Kury, Faiza Nasar, Abdullah Alattar, Reem Alshaman, Fawad Ali Shah, Arif-Ullah Khan, Shupeng Li
Natural Dietary Supplement, Carvacrol, Alleviates Lps-Induced Oxidative Stress, Neurodegeneration, And Depressive-Like Behaviors Via The Nrf2/Ho-1 Pathway, Komal Naeem, Lina Tariq Al Kury, Faiza Nasar, Abdullah Alattar, Reem Alshaman, Fawad Ali Shah, Arif-Ullah Khan, Shupeng Li
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Major depressive disorder (MDD) is a debilitating human health condition characterized by mood swings and is associated with a high probability of suicide attempts. Several studies have reported a role of neuroinflammation in MMD, yet the efficacy of natural drug substances on neuroinflammation-associated depression has not been well-investigated. The present study examined the neuroprotective effects of carvacrol on lipopolysaccharide (LPS)-induced neuroinflammation, depression, and anxiety-like behavior. Methods Male Sprague Dawley rats were divided into two experimental cohorts to determine the effects and the effective dose of carvacrol (whether 20 mg/kg or 50 mg/kg), and further demonstrate the mechanism of action of …
Carveol A Naturally-Derived Potent And Emerging Nrf2 Activator Protects Against Acetaminophen-Induced Hepatotoxicity, Zaif Ur Rahman, Lina Tariq Al Kury, Abdullah Alattar, Zhen Tan, Reem Alshaman, Imran Malik, Haroon Badshah, Zia Uddin, Atif Ali Khan Khalil, Naveed Muhammad, Saifullah Khan, Amjad Ali, Fawad Ali Shah, Jing Bo Li, Shupeng Li
Carveol A Naturally-Derived Potent And Emerging Nrf2 Activator Protects Against Acetaminophen-Induced Hepatotoxicity, Zaif Ur Rahman, Lina Tariq Al Kury, Abdullah Alattar, Zhen Tan, Reem Alshaman, Imran Malik, Haroon Badshah, Zia Uddin, Atif Ali Khan Khalil, Naveed Muhammad, Saifullah Khan, Amjad Ali, Fawad Ali Shah, Jing Bo Li, Shupeng Li
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Acetaminophen (N-acetyl p-aminophenol or APAP) is used worldwide for its antipyretic and anti-inflammatory potential. However, APAP overdose sometimes causes severe liver damage. In this study, we elucidated the protective effects of carveol in liver injury, using molecular and in silico approaches. Male BALB/c mice were divided into two experimental cohorts, to identify the best dose and to further assess the role of carveol in the nuclear factor E2-related factor; nuclear factor erythroid 2; p45-related factor 2 (Nrf2) pathway. The results demonstrated that carveol significantly modulated the detrimental effects of APAP by boosting endogenous antioxidant mechanisms, such as nuclear translocation of …