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Full-Text Articles in Medicine and Health Sciences
Evaluating The Feasibility Of Pro-Neurotensin And 25-Hydroxyvitamin D3 As Possible Indicators For Type 2 Diabetes Mellitus And Its Complications, Amal A. Mohammed, Dina M. Abo El-Matty, Esraa A. Abd Elsalam, Mona A. Hussein, Wael Hafez, Sharehan A. Ibrahim, Eman A. H. Shaheen, Eman A. Awad, Marwa A. Osman, Marwa S. Abd El-Raouf, Salma M. Saed, Reham Y. El-Amir, Doaa Ghaith, Fatme Al Anouti, Alaa S. Wahba
Evaluating The Feasibility Of Pro-Neurotensin And 25-Hydroxyvitamin D3 As Possible Indicators For Type 2 Diabetes Mellitus And Its Complications, Amal A. Mohammed, Dina M. Abo El-Matty, Esraa A. Abd Elsalam, Mona A. Hussein, Wael Hafez, Sharehan A. Ibrahim, Eman A. H. Shaheen, Eman A. Awad, Marwa A. Osman, Marwa S. Abd El-Raouf, Salma M. Saed, Reham Y. El-Amir, Doaa Ghaith, Fatme Al Anouti, Alaa S. Wahba
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(1) Background: Type 2 diabetes mellitus (T2DM) and metabolic syndrome are associated with decreased vitamin D. In contrast, high pro-neurotensin (pro-NT) levels are linked with an increased risk of T2DM and cardiovascular disease. We aimed to determine the validity of pro-NT and 25-dihydroxy vitamin D3 levels as predictors for T2DM complications; (2) Methods: One hundred T2DM, and one hundred healthy volunteers participated in this case-control study. Their Pro-NT and 25-hydroxyvitamin D3 levels were evaluated using the ELISA technique; (3) Results: Pro-NT and 25 (OH) vitamin D3 have significant validity and accuracy in T2DM prediction, 84.5%, and 90.5%, respectively (p = …
The Association Of Peptide Hormones With Glycemia, Dyslipidemia, And Obesity In Lebanese Individuals, Murielle Abou-Samra, Koen Venema, Carole Ayoub Moubareck, Mirey Karavetian
The Association Of Peptide Hormones With Glycemia, Dyslipidemia, And Obesity In Lebanese Individuals, Murielle Abou-Samra, Koen Venema, Carole Ayoub Moubareck, Mirey Karavetian
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Peptide-hormones, including pancreatic peptide-YY(PYY), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), insulin, and leptin function as satiety signals, while ghrelin promotes hunger. These hormones are also involved in glucose homeostasis and body-weight regulation. The aim of this cross-sectional analysis was to examine the association of these peptide-hormones with obesity-markers, insulin-resistance, and dyslipidemia (total-cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), high-density-lipoprotein-cholesterol (HDL-C), triglyceride (TG)). Sixteen-obese (OB) adults and 21 normal-weight (NW) age-and gender-matched counterparts were recruited. OB-participants showed significantly higher levels of leptin, insulin, Homeostatic-Model Assessment of Insulin Resistance (HOMA-IR), and TG. NW participants had significantly higher levels of ghrelin. GLP-1 was positively correlated with insulin, …
The Association Between Peptide Hormones With Obesity And Insulin Resistance Markers In Lean And Obese Individuals In The United Arab Emirates, Manal Ali Ahmad, Mirey Karavetian, Carole Ayoub Moubareck, Gabi Wazz, Tarek Mahdy, Koen Venema
The Association Between Peptide Hormones With Obesity And Insulin Resistance Markers In Lean And Obese Individuals In The United Arab Emirates, Manal Ali Ahmad, Mirey Karavetian, Carole Ayoub Moubareck, Gabi Wazz, Tarek Mahdy, Koen Venema
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Peptide hormones play a crucial role in body weight and glucose homeostasis. In this study, we aimed to explore this association and recruited 43 obese and 31 age-and sex-matched lean participants. We assessed their body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), percentage body fat (PBF), fasting blood levels of peptide hormones (GLP-1, GLP-2, insulin, leptin, ghrelin, CCK, and PYY), fasting blood sugar (FBS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). We tested the associations between peptide hormones and markers of obesity and insulin resistance (IR) by using the Independent-Samples t-test and Mann-Whitney U test, partial correlation, …
Obese Children With Metabolic Syndrome Have 3 Times Higher Risk To Have Nonalcoholic Fatty Liver Disease Compared With Those Without Metabolic Syndrome, Dimitrios Papandreou, Mirey Karavetian, Zacharoula Karabouta, Eleni Andreou
Obese Children With Metabolic Syndrome Have 3 Times Higher Risk To Have Nonalcoholic Fatty Liver Disease Compared With Those Without Metabolic Syndrome, Dimitrios Papandreou, Mirey Karavetian, Zacharoula Karabouta, Eleni Andreou
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Copyright © 2017 Dimitrios Papandreou et al. Background: The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods: Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. Results: Forty-four children (58.6%) were found to have MS. Insulin resistance was present in 78 (62.4%) children. Patients with MS were more likely to have NAFLD (P <; 0.001). Children with NAFLD had significantly higher body mass index, waist circumference, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal livers (P < 0.001). Insulin resistance was significantly higher in children with NAFLD (P <; 0.001). Obese children presenting with MS were 3.01 (2.87-3.57, P < 0.002) times more likely to develop NAFLD compared to those without metabolic syndrome after adjustment of cofounders. Conclusions: Obese children with MS have a higher risk of developing NAFLD. Weight management and early prevention should be the first line of treatment to prevent any possible health issues later on.
Role Of Diet On Non-Alcoholic Fatty Liver Disease: An Updated Narrative Review, Dimitrios Papandreou, Eleni Andreou
Role Of Diet On Non-Alcoholic Fatty Liver Disease: An Updated Narrative Review, Dimitrios Papandreou, Eleni Andreou
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© 2015 Baishideng Publishing Group Inc. The purpose of this article review is to update what is known about the role of diet on non-alcoholic fatty liver disease (NAFLD). NAFLD is the most common cause of chronic liver disease in the developed world and is considered to be a spectrum, ranging from fatty infiltration of the liver alone (steatosis), which may lead to fatty infiltration with inflammation known as non alcoholic steatohepatitis While the majority of individuals with risk factors like obesity and insulin resistance have steatosis, only few people may develop steatohepatitis. Current treatment relies on weight loss and …