Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Histopathology And Image Validation Of Outer Retinal Tubulations In Age-Related Macular Degeneration, Katie M. Litts
Histopathology And Image Validation Of Outer Retinal Tubulations In Age-Related Macular Degeneration, Katie M. Litts
All ETDs from UAB
High-resolution imaging of the retina using spectral domain optical coherence tomography (SD-OCT) and adaptive optics scanning laser ophthalmoscopy (AOSLO) is revealing new information about photoreceptor degeneration in age-related macular degeneration (AMD) and other diseases impacting rod and cone photoreceptors. By SD-OCT, the hyperreflective outer retinal bands are visible due to the precise vertical compartmentalization and horizontal alignment of outer retinal cells and tissues (Müller cells, photoreceptors, RPE, and Bruch’s membrane). Validating these bands with normal eyes is difficult because the outer retina is very delicate making accurate histology requiring attached retina and vertically aligned photoreceptors challenging. Conversely, the bands are …
Elementary Photoreceptor Signaling In Human Vision, Kady Scarlett Bruce
Elementary Photoreceptor Signaling In Human Vision, Kady Scarlett Bruce
All ETDs from UAB
To perceive a spot of light at photopic threshold, a minimum number of photons must be absorbed by cone photoreceptors. While many factors affecting psychophysical threshold have been studied, few have been examined at the single-cone level. Here we reveal how variation in synaptic weighting and signal integration among cones in the human retina occurs in vivo. Using an adaptive optics scanning laser ophthalmoscope (AOSLO) equipped with stimulation capabilities, we targeted cone-sized stimuli to single cones. Perceptual increment thresholds were measured from individual cones and cone pairs in 7 subjects using a Bayesian-based staircase method of threshold estimation. In 42 …
Chromatic Sensitivity: A New Insight Into Color Discrimination, Micah Jason Kinney
Chromatic Sensitivity: A New Insight Into Color Discrimination, Micah Jason Kinney
All ETDs from UAB
Color discrimination varies between individuals even in the absence of a congenital color vision defect. Attempts to explain this variation have shown no link to macular pigment optical density, L:M cone ratios, non-verbal IQ, or female carriers of color vision deficiencies. This study examined individuals’ relative luminance and color-opponent systems sensitivity to their Farnsworth-Munsell 100-Hue (FM-100) color discrimination ability. Thirty normal color vision subjects performed FM-100 and increment threshold testing for white, blue, green and red on a 150 cd/m2 white background. White increment thresholds were compared to colored increment thresholds to produce a luminance to color-opponent system sensitivity ratio …