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Full-Text Articles in Medicine and Health Sciences
Killer Cell Activation By A Novel Multifunctional Protein: An Immuno/Gene Therapy For Cancer, Ashlee Tietje
Killer Cell Activation By A Novel Multifunctional Protein: An Immuno/Gene Therapy For Cancer, Ashlee Tietje
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One of the characteristics of advanced tumors is the evasion of the immune system. There are multiple methods that tumor cells employ to achieve this including reducing the expression of activating ligands on the cell surface and a shift in the tumor microenvironment toward pro-tumor cytokines. The purpose of this research is to develop a novel bifunctional fusion protein that will target these two deficiencies in the tumor microenvironment and activate killer cells that are already present. The proposed protein combines the extracellular domain of a ligand for the killer cell activating receptor NKG2D and Interleukin-12 (IL-12). It is hypothesized …
Effects Of Red Raspberry On Doxorubicin Chemotherapy Induced Neurotoxicity, Ran He
Effects Of Red Raspberry On Doxorubicin Chemotherapy Induced Neurotoxicity, Ran He
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Chemotherapy is a widely used treatment for cancer, with significant side effects including cognitive impairments that affect patients' quality of life. Red raspberries are known to inhibit growth of cancer cells with recent research suggesting the ability to also protect neurons. If this protective ability can be confirmed, red raspberry may emerge as a promising natural intervention for cognitive impairments associated with chemotherapy. In addition, many studies have linked cognitive functions to epigenetic mechanisms postulating that transient reprogramming of epigenetic mechanisms, such as DNA methylation, is required for some basic neuronal/cognitive functions.
The objective of this dissertation is to study …
Characterization Of The Anti-Angiogenic Properties Of Kdr-Ig4-7 And Its Variants As Potential Anti-Cancer Therapeutics, Jang Pyo Park
Characterization Of The Anti-Angiogenic Properties Of Kdr-Ig4-7 And Its Variants As Potential Anti-Cancer Therapeutics, Jang Pyo Park
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Beginning with the development of an embryo and throughout one's adult life angiogenesis plays an essential role for organ growth and repair. The balancing of pro-angiogenic factors to anti-angiogenic factors is what regulates the process of angiogenesis. When this balance is disrupted in one direction or the other, numerous disorders can occur including ocular and inflammatory diseases and, in particular, tumor growth and metastasis. Therefore, inhibition of angiogenesis has become an effective therapy for arresting the growth of tumors.
A key regulator of angiogenesis involves vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2 (KDR). The binding of VEGF to …