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Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 13, 2012, Wright State University Office Of Undergraduate Research And Stemm Activities
Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 13, 2012, Wright State University Office Of Undergraduate Research And Stemm Activities
Symposium of Student Research, Scholarship, and Creative Activities Materials
The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's second annual Celebration of Research, Scholarship and Creative Activities on April 13, 2012.
Eti‐385 As A Novel Anti‐Emetic Against Drug Induced Emesis, Theresa Fennell, James Lucot, Samantha Spitak, Emily Smith, Teresa Garret
Eti‐385 As A Novel Anti‐Emetic Against Drug Induced Emesis, Theresa Fennell, James Lucot, Samantha Spitak, Emily Smith, Teresa Garret
Symposium of Student Research, Scholarship, and Creative Activities Materials
Drugs currently used to prevent emesis (nausea and vomiting) target only one or a few of the pathways used by emetic stimuli to trigger the reflex. Thus, an anti-emetic drug will only be effective against some stimuli. Prior work determined that 8-OH-DPAT (DPAT, a 5-HT1A agonist) was a universally effective anti-emetic. Although DPAT prevented emesis, it also elicited an extreme anxiety response making it unsuitable for therapeutic use. Presently, there exists no universal anti-emetic drug. We tested a proprietary drug developed from DPAT, ETI-385, which successfully prevented emesis in musk shrews against chemotherapy, drug and motion stimuli. For FDA purposes, …