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The Role Of Corticotropin-Releasing Factor In The Behavior And Proinflammatory Activity Of Separated Guinea Pig Pups, Vincent Rasahd Alexander
The Role Of Corticotropin-Releasing Factor In The Behavior And Proinflammatory Activity Of Separated Guinea Pig Pups, Vincent Rasahd Alexander
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Isolation of guinea pig pups in a novel environment first produces active behaviors such as vocalizing and movement; over time, these behaviors wane and pups show characteristic passive responses similar to those produced by increased proinflammatory activity. Further, isolation of pups on two consecutive days has recently been shown to enhance those passive responses on the second day. Endogenous proinflammatory activity is thought to mediate the enhancement (sensitization). An injection of corticotropin-releasing factor (CRF) has been shown to increase passive behavior, possibly by increasing proinflammatory activity. The present study further investigated the role of CRF on proinflammatory activity and behavior …
Persisiting Sensitization Of Depressive-Like Behavior And Thermogenic Response During Maternal Separation In Pre- And Post Weaning Guinea Pigs, Randi Lynn Schneider
Persisiting Sensitization Of Depressive-Like Behavior And Thermogenic Response During Maternal Separation In Pre- And Post Weaning Guinea Pigs, Randi Lynn Schneider
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Early attachment disruption is thought to promote later onset of depressive illness through a process involving sensitization. Maternal separation in guinea pig pups (~21 days of age) produces depressive-like behavior and core body temperature fluctuations that appear to be mediated by proinflammatory activity. These responses are enhanced during repeated separations over several days. Here, enhanced depressive-like behavior and core body temperature responses were observed from the early pre-weaning to the periadolescent period (~10-40 days of age) and persisted for more than a week. The greatest temperature response was observed during the final separation. These results demonstrate persisting sensitization of behavioral …
Sensitization Of Behavioral Response To Maternal Separation: Persistence Of The Effect And Role Of Proinflammatory Activity, Jessie Caraway
Sensitization Of Behavioral Response To Maternal Separation: Persistence Of The Effect And Role Of Proinflammatory Activity, Jessie Caraway
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Maternal separation in guinea pigs produces a biphasic response consisting of an active behavior phase followed by a phase of passive behavior (crouched stance, piloerection, and eye closure). Previous studies suggest that pro-inflammatory cytokines mediate passive behavior during the passive phase. It is also known that guinea pig pups separated on two consecutive days show a significant increase (sensitization) in full passive behavior on the second day. The current study examined the persistence and role of pro-inflammatory activity in the sensitization of passive behavior in maternally separated guinea pigs. Guinea pig pups were assigned to one of four groups differing …
Inhibition Of Pro-Inflammatory Processes Reduces Sensitization Of The Behavioral Response To Maternal Separation, Kristopher Doojin Paik
Inhibition Of Pro-Inflammatory Processes Reduces Sensitization Of The Behavioral Response To Maternal Separation, Kristopher Doojin Paik
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The current study examined the behavioral sensitization of guinea pig pups in response to consecutive days of maternal separation. In the first experiment, guinea pigs that received centrally administered artificial cerebrospinal fluid or IL-10 exhibited sensitization of passive behaviors from Day 1 to Day 2. IL-10 decreased the levels of passive behaviors on Day 1, as well as the increase on Day 2. The second experiment used unoperated pups, which also showed sensitization of the passive response from Day 1 to Day 2, though the effect appeared reduced relative to control pups of Experiment 1. Collectively, this investigation confirms previous …
Stress Reducing Effects Of Oxytocin In A Maternal Separation Paradigm, Keely Jane O'Connell
Stress Reducing Effects Of Oxytocin In A Maternal Separation Paradigm, Keely Jane O'Connell
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This study compared the effects of centrally and peripherally administered oxytocin (OT) on HPA axis activity and the presence of both stress-induced active and passive behaviors in female guinea pig pups (Cavia porcellus) after 180-min of isolation . In Experiment 1, one dose of oxytocin (10μg/.2ml) was injected subcutaneously into the periphery. Plasma cortisol levels were reduced after 180-min of isolation and two passive behaviors, eye-closure and crouch, were reduced as well with the administration of oxytocin. In Experiment 2, two different doses (10μg/.2ml and 20μg/.2ml) were injected into the periphery with no significant results. In Experiment 3 one dose …