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Short-Term Administration Of Corticosterone Has Lasting Effects On Learning In Young Rats, Christine L. Wentworth-Eidsaune
Short-Term Administration Of Corticosterone Has Lasting Effects On Learning In Young Rats, Christine L. Wentworth-Eidsaune
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Corticosterone is a glucocorticoid released as part of the body's response to stress and is known to affect cognitive function, presumably via effects on the hippocampus. Trace classical eyeblink conditioning depends on the hippocampus, and has been used to examine the development of learning processes in young organisms. Experiment 1 was a dosing study, in which time course of effect of corticosterone was followed in 15-day-old Long-Evans rat pups over 24 hours for 4 different concentrations (high: 0.02 mg/g body weight (b.w.), medium: 0.01mg/g b.w., low: 0.005 mg/g b.w. and a vehicle control). In Experiment 2, two subcutaneous injections (0.02 …
Effects Of Subcutaneous Postnatal Choline Supplementation On Hippocampus-Mediated Learning And Memory In Rat Pups, Jeremy Alan Moore
Effects Of Subcutaneous Postnatal Choline Supplementation On Hippocampus-Mediated Learning And Memory In Rat Pups, Jeremy Alan Moore
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The effects of postnatal injections of choline on the acquisition of two variants of eyeblink conditioning were examined in developing Long-Evans rat pups. Choline administration on postnatal days (PND) 15-27 was followed by evaluation of trace eyeblink conditioning (Experiment 1) and delay eyeblink conditioning (Experiment 2) on PND 28-29. The results of these experiments show that choline produced greater improvements in learning and memory during the trace condition than in the delay condition, presumably due to its effect on the hippocampus. Trace eyeblink conditioning relies heavily on an intact hippocampus but delay eyeblink conditioning does not, and it is understood …