Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Connectivity Of Monosynaptic Ia Afferents On Renshaw Cells In Neonatal Mice, Todd Joseph Rapetti
Connectivity Of Monosynaptic Ia Afferents On Renshaw Cells In Neonatal Mice, Todd Joseph Rapetti
Browse all Theses and Dissertations
Proprioception allows sensory information about muscle position and length to enter the CNS without the aid of visual cues. One type of fiber that carries this information is the Ia afferent, which innervates muscle spindles that respond to mechanical perturbation in muscle. Ia fibers are known to synapse with Ia interneurons (INs) and motor neurons (MNs), setting up important circuits which affect movement. Another type of IN is the Renshaw cell (RC), which is located in the ventral part of lamina VII of the spinal cord and is critical for the functionality of the recurrent inhibitory circuit. In addition to …
Reorganization Of Ia Afferent Synapses On Motoneurons After Peripheral Nerve Injuries, Haley E. Titus
Reorganization Of Ia Afferent Synapses On Motoneurons After Peripheral Nerve Injuries, Haley E. Titus
Browse all Theses and Dissertations
After peripheral nerve injuries patients lose and do not recover the stretch reflex which leads to altered locomotor function. The focus of this thesis is to investigate the structural integrity of the central connection between Ia afferents and alpha motoneurons that mediate the stretch reflex. The overall hypothesis is that the density and distribution of Ia synapses on motoneurons is altered after peripheral nerve injuries. Analysis of Ia afferent-motoneuron contacts, revealed by vesicular glutamate transporter 1 (VGLUT1) immunoreactivity, on the soma and dendritic arbor of motoneurons after peripheral nerve injuries revealed major reorganizations in the distribution and density of Ia …