Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Persisiting Sensitization Of Depressive-Like Behavior And Thermogenic Response During Maternal Separation In Pre- And Post Weaning Guinea Pigs, Randi Lynn Schneider
Persisiting Sensitization Of Depressive-Like Behavior And Thermogenic Response During Maternal Separation In Pre- And Post Weaning Guinea Pigs, Randi Lynn Schneider
Browse all Theses and Dissertations
Early attachment disruption is thought to promote later onset of depressive illness through a process involving sensitization. Maternal separation in guinea pig pups (~21 days of age) produces depressive-like behavior and core body temperature fluctuations that appear to be mediated by proinflammatory activity. These responses are enhanced during repeated separations over several days. Here, enhanced depressive-like behavior and core body temperature responses were observed from the early pre-weaning to the periadolescent period (~10-40 days of age) and persisted for more than a week. The greatest temperature response was observed during the final separation. These results demonstrate persisting sensitization of behavioral …
Inhibition Of Pro-Inflammatory Processes Reduces Sensitization Of The Behavioral Response To Maternal Separation, Kristopher Doojin Paik
Inhibition Of Pro-Inflammatory Processes Reduces Sensitization Of The Behavioral Response To Maternal Separation, Kristopher Doojin Paik
Browse all Theses and Dissertations
The current study examined the behavioral sensitization of guinea pig pups in response to consecutive days of maternal separation. In the first experiment, guinea pigs that received centrally administered artificial cerebrospinal fluid or IL-10 exhibited sensitization of passive behaviors from Day 1 to Day 2. IL-10 decreased the levels of passive behaviors on Day 1, as well as the increase on Day 2. The second experiment used unoperated pups, which also showed sensitization of the passive response from Day 1 to Day 2, though the effect appeared reduced relative to control pups of Experiment 1. Collectively, this investigation confirms previous …
Stress Reducing Effects Of Oxytocin In A Maternal Separation Paradigm, Keely Jane O'Connell
Stress Reducing Effects Of Oxytocin In A Maternal Separation Paradigm, Keely Jane O'Connell
Browse all Theses and Dissertations
This study compared the effects of centrally and peripherally administered oxytocin (OT) on HPA axis activity and the presence of both stress-induced active and passive behaviors in female guinea pig pups (Cavia porcellus) after 180-min of isolation . In Experiment 1, one dose of oxytocin (10μg/.2ml) was injected subcutaneously into the periphery. Plasma cortisol levels were reduced after 180-min of isolation and two passive behaviors, eye-closure and crouch, were reduced as well with the administration of oxytocin. In Experiment 2, two different doses (10μg/.2ml and 20μg/.2ml) were injected into the periphery with no significant results. In Experiment 3 one dose …