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Full-Text Articles in Medicine and Health Sciences
Characterization Of Inhbb, Heatr5a, & Cyp2s1 Expression In Dorsal Root Ganglia By In-Situ Hybridization, Joshua D. Krech
Characterization Of Inhbb, Heatr5a, & Cyp2s1 Expression In Dorsal Root Ganglia By In-Situ Hybridization, Joshua D. Krech
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Multiple studies have shown that gene expression changes occur in sensory neurons after peripheral nerve injury (PNI). These expression changes include many genes that are turned on specifically in response to injury, but much less is know about expression changes in stable genetic markers of particular sensory neuron populations. This study characterized the expression of three markers of proprioceptive neurons Inhbb, Heatr5a, Cyp2s1 in lumbar dorsal root ganglion (DRG) neurons in intact animals and after PNI. To perform these experiments, we subcloned segments of the coding sequences of these genes and generated DIG-labeled riboprobes. Control experiments demonstrated the validity of …
Using Fmri Bold Imaging To Motion-Correct Associated, Simultaneously Imaged Pet Data, Joseph M. Williamitis
Using Fmri Bold Imaging To Motion-Correct Associated, Simultaneously Imaged Pet Data, Joseph M. Williamitis
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Because magnetic resonance (MR) and positron emission tomography (PET) scanning sessions last long durations, motion blur during scanning constitutes a problem for clinical interpretation. To counteract this, motion-correction algorithms have been developed to reduce smearing between scan slices of MRI, but these algorithms are not commonplace for PET. This feasibility study determined if applying MRI motion-correction algorithms to simultaneously acquired PET data improved PET signal clarity in specific brain regions. Seven subjects received increasing levels of PET tracers while undergoing two separate simultaneous PET/MRI scans. We modified existing fMRI algorithms to apply them to the accompanying PET data. We hypothesized …
The Role Of Igf-1 In Geriatric Skin, Amber Castellanos
The Role Of Igf-1 In Geriatric Skin, Amber Castellanos
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Keratinocytes are cells that largely occupy the epidermis layer of our skin and function to protect against DNA damage induced by ultraviolet radiation. Keratinocytes rely on the activation of the IGF-1 receptor in order to carry out an appropriate response to UV-B radiation. Keratinocytes themselves do not express the IGF-1 ligand; IGF-1 is produced by fibroblasts found in the dermis layer of the skin. With age, fibroblasts become senescent and this interferes with their ability to produce IGF-1 for the epidermal IGF-1R. This occurrence may aid in understanding why geriatric individuals are at greatest risk for developing nonmelanoma skin cancers, …
Impact Of Passive Range Of Motion Exercises And Stretching In Knee Osteoarthritis Pain During Walking, Dominique Marchelle Ottonello
Impact Of Passive Range Of Motion Exercises And Stretching In Knee Osteoarthritis Pain During Walking, Dominique Marchelle Ottonello
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Knee osteoarthritis (KOA), is globally prevalent source of disability for the elderly. This degenerative malady progresses with age and has no cure. It manifests in gait changes and affects overall quality of life. Exercise therapy has been shown to improve knee joint range of motion, stiffness and pain due to KOA. This improvement is due in part to the direct relationship between muscle strength and joint stability. The purpose of this study is to examine how a passive range of motion (ROM) exercises and stretching regimens affect gait-alterations and associated pain from KOA experienced during walking. Nine KOA subjects were …
Assessment Of Pseudo-Continuous Arterial Spin Labeling (Pcasl) Inter-Session Reliability In The Quantification Of Cerebral Perfusion, Mohammad Ahmad Awad
Assessment Of Pseudo-Continuous Arterial Spin Labeling (Pcasl) Inter-Session Reliability In The Quantification Of Cerebral Perfusion, Mohammad Ahmad Awad
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Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) technique used for measuring cerebral blood flow (CBF) in a completely non-ionizing and non invasive fashion. ASL is useful in perfusion studies on healthy adult & pediatric subjects, individuals who need multiple follow-ups, and patients with varying cerebrovascular diseases where changes in CBF can be used as an indicator of tissue viability. We used a variation of the ASL technique known as pseudo-continuous ASL (pCASL). This form of ASL is the clinical standard (Alsop et al., 2015). However, it is not well documented the that pCASL is reliable between sessions …
Effect Of Hybrid/Complex N-Glycosylation On Cardiac Voltage-Gated Ion Channel Expression, Austin R. Parrish
Effect Of Hybrid/Complex N-Glycosylation On Cardiac Voltage-Gated Ion Channel Expression, Austin R. Parrish
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Dilated cardiomyopathy (DCM) is one the most common forms of heart failure, with the majority of cases being idiopathic. Dr. Bennett’s laboratory previously showed that deletion of the Mgat1 gene in cardiomyocytes only (Mgat1KO) is sufficient to cause DCM leading to heart failure and early death. The Mgat1 gene product, GlcNAcT1, is responsible for initiating the formation of hybrid/complex N-glycosylation. These data suggest a link between abnormal glycosylation and heart disease; however, there is a mystery of how the specific changes in glycosylation contribute to heart disease etiology and progression. The proper function and gating of voltage-gated Na+ channels (Nav) …