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Full-Text Articles in Medicine and Health Sciences
Persisiting Sensitization Of Depressive-Like Behavior And Thermogenic Response During Maternal Separation In Pre- And Post Weaning Guinea Pigs, Randi Lynn Schneider
Persisiting Sensitization Of Depressive-Like Behavior And Thermogenic Response During Maternal Separation In Pre- And Post Weaning Guinea Pigs, Randi Lynn Schneider
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Early attachment disruption is thought to promote later onset of depressive illness through a process involving sensitization. Maternal separation in guinea pig pups (~21 days of age) produces depressive-like behavior and core body temperature fluctuations that appear to be mediated by proinflammatory activity. These responses are enhanced during repeated separations over several days. Here, enhanced depressive-like behavior and core body temperature responses were observed from the early pre-weaning to the periadolescent period (~10-40 days of age) and persisted for more than a week. The greatest temperature response was observed during the final separation. These results demonstrate persisting sensitization of behavioral …
Aquaporin 4 Expression And Distribution During Osmotic Brain Edema And Following Chronic Treatment Of Desipramine, Sergei Alexander Robinson
Aquaporin 4 Expression And Distribution During Osmotic Brain Edema And Following Chronic Treatment Of Desipramine, Sergei Alexander Robinson
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Osmotic brain edema or chronic treatment with desipramine alters brain water permeability. In this study we investigated aquaporin 4 expression and distribution in these two conditions. Brain edema development was induced by intraperitoneal water injection. Blood serum osmolality decreased from 296 ± 1 mOsm to 278 ± 2 mOsm within 15 min. Cerebral cortex water content increased from 79.8 ± 0.2 % to 81.3 ± 0.5% during 120 min of this hyposmotic exposure. Aquaporin 4 immunostaining intensity at the astrocytic endfeet increased in water injected animals from 2.6 ± 0.04 intensity unites (IU) to 3.2 ± 0.21 IU, while total …