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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
The Role Of Apoptosis In Hela Cells Expressing Hiv-1 Rev, Elizabeth Page
The Role Of Apoptosis In Hela Cells Expressing Hiv-1 Rev, Elizabeth Page
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The HIV protein Rev is a nucleolar protein that regulates late gene expression in infected cells by promoting the export of under-spliced viral RNAs (Pollard and Malim, 1998). Its over-expression can also inhibit progression through mitosis (Miyazaki et al., 1995), possibly through its ability to depolymerize microtubules (Watts et al., 2000). Consequently, Rev may activate the spindle assembly checkpoint in mitotic cells and increase the frequency of apoptosis. Rev also binds the nucleolar protein B23 involved in ribosome maturation and centrosome duplication. Because loss of B23 function stimulates apoptosis (Ahn et al., 2005), Rev expression may promote apoptosis by inhibiting …
Sensitization Of Behavioral Response To Maternal Separation: Persistence Of The Effect And Role Of Proinflammatory Activity, Jessie Caraway
Sensitization Of Behavioral Response To Maternal Separation: Persistence Of The Effect And Role Of Proinflammatory Activity, Jessie Caraway
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Maternal separation in guinea pigs produces a biphasic response consisting of an active behavior phase followed by a phase of passive behavior (crouched stance, piloerection, and eye closure). Previous studies suggest that pro-inflammatory cytokines mediate passive behavior during the passive phase. It is also known that guinea pig pups separated on two consecutive days show a significant increase (sensitization) in full passive behavior on the second day. The current study examined the persistence and role of pro-inflammatory activity in the sensitization of passive behavior in maternally separated guinea pigs. Guinea pig pups were assigned to one of four groups differing …
Presynaptic Regulation Of Carotid Body Type I Cells By Histaminergic And Muscarinic Receptors, Carrie Marie Thompson
Presynaptic Regulation Of Carotid Body Type I Cells By Histaminergic And Muscarinic Receptors, Carrie Marie Thompson
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Type I cells are one of two main cell types located within the carotid body. These cells respond to hypoxia, hypercapnia, and acidosis by releasing excitatory and inhibitory neurotransmitters. This causes increased firing of the carotid sinus nerve and restores blood gas levels to their physiological values. While previous studies have shown whether individual neurotransmitters are excitatory or inhibitory, this work demonstrates how the interplay between two neurotransmitters may potentially shape the output of the carotid body. Histamine, which has previously been shown to have no effect on intracellular Ca2+ in type I cells, may function to modulate the actions …
Short-Term Administration Of Corticosterone Has Lasting Effects On Learning In Young Rats, Christine L. Wentworth-Eidsaune
Short-Term Administration Of Corticosterone Has Lasting Effects On Learning In Young Rats, Christine L. Wentworth-Eidsaune
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Corticosterone is a glucocorticoid released as part of the body's response to stress and is known to affect cognitive function, presumably via effects on the hippocampus. Trace classical eyeblink conditioning depends on the hippocampus, and has been used to examine the development of learning processes in young organisms. Experiment 1 was a dosing study, in which time course of effect of corticosterone was followed in 15-day-old Long-Evans rat pups over 24 hours for 4 different concentrations (high: 0.02 mg/g body weight (b.w.), medium: 0.01mg/g b.w., low: 0.005 mg/g b.w. and a vehicle control). In Experiment 2, two subcutaneous injections (0.02 …
Developmental Expression Of Calcium Buffering Proteins In Central Auditory Pathways Of Normal Hearing And Congenitally Deaf Mice, Adam S. Deardorff
Developmental Expression Of Calcium Buffering Proteins In Central Auditory Pathways Of Normal Hearing And Congenitally Deaf Mice, Adam S. Deardorff
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These experiments analyze differences in synaptic development in central auditory pathways between normal hearing (CBA/J) and congenitally deaf (dn/dn) mice, which provide valuable insight into central synaptic plasticity corresponding to human congenital deafness. Immunofluorescent analysis of the developmental expression of the calcium buffering proteins calretinin, calbindin d-28k, and parvalbumin at various postnatal time points was performed to assess the effects of altered neural activity on the level and/or pattern of protein expression within these nuclei. Results indicate that the pattern of calbindin and parvalbumin is unaffected by congenital deafness in dn/dn mice. However, the pattern of calretinin expression in the …