Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Inhibition Of Pro-Inflammatory Processes Reduces Sensitization Of The Behavioral Response To Maternal Separation, Kristopher Doojin Paik
Inhibition Of Pro-Inflammatory Processes Reduces Sensitization Of The Behavioral Response To Maternal Separation, Kristopher Doojin Paik
Browse all Theses and Dissertations
The current study examined the behavioral sensitization of guinea pig pups in response to consecutive days of maternal separation. In the first experiment, guinea pigs that received centrally administered artificial cerebrospinal fluid or IL-10 exhibited sensitization of passive behaviors from Day 1 to Day 2. IL-10 decreased the levels of passive behaviors on Day 1, as well as the increase on Day 2. The second experiment used unoperated pups, which also showed sensitization of the passive response from Day 1 to Day 2, though the effect appeared reduced relative to control pups of Experiment 1. Collectively, this investigation confirms previous …
Reorganization Of Ia Afferent Synapses On Motoneurons After Peripheral Nerve Injuries, Haley E. Titus
Reorganization Of Ia Afferent Synapses On Motoneurons After Peripheral Nerve Injuries, Haley E. Titus
Browse all Theses and Dissertations
After peripheral nerve injuries patients lose and do not recover the stretch reflex which leads to altered locomotor function. The focus of this thesis is to investigate the structural integrity of the central connection between Ia afferents and alpha motoneurons that mediate the stretch reflex. The overall hypothesis is that the density and distribution of Ia synapses on motoneurons is altered after peripheral nerve injuries. Analysis of Ia afferent-motoneuron contacts, revealed by vesicular glutamate transporter 1 (VGLUT1) immunoreactivity, on the soma and dendritic arbor of motoneurons after peripheral nerve injuries revealed major reorganizations in the distribution and density of Ia …
The Presynaptic Regulation Of Isolated Neonatal Rat Carotid Body Type I Cells By Histamine, Drew C. Burlon
The Presynaptic Regulation Of Isolated Neonatal Rat Carotid Body Type I Cells By Histamine, Drew C. Burlon
Browse all Theses and Dissertations
It has been previously shown that Carotid Body Type I cells have the ability to synthesize, package and release histamine in response to hypoxia, thereby contributing to the modulation of respiration within the rat. Here, isolated neonatal rat carotid body type I cells were used to identify the presynaptic effects of histamine and the specific receptor subtypes that modulate them. Although all four histamine receptor subtypes are expressed on the type I cells, and preliminary data showed promising results, further data proved that the activation of these receptors with histamine or selective agonists caused no rise in intracellular calcium ([Ca2+]i) …