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Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Western University

2017

EMT

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Full-Text Articles in Medicine and Health Sciences

Daily Hydrogen Sulfide Treatment Enables Early Recovery Of Renal Function And Mitigates Renal Injury Following The Relief Of Prolonged Urinary Obstruction, Shouzhe Lin Jun 2017

Daily Hydrogen Sulfide Treatment Enables Early Recovery Of Renal Function And Mitigates Renal Injury Following The Relief Of Prolonged Urinary Obstruction, Shouzhe Lin

Electronic Thesis and Dissertation Repository

Prolonged urinary obstruction can lead to renal dysfunction and irreversible injury. The recovery of renal function following decompression is heavily dependent on the degree of renal injury. This suggests that treatments aimed at mitigating renal injury could improve the recovery of renal function following decompression. Previous studies have shown that hydrogen sulfide (H2S), an endogenous gasotransmitter, can reduce the histopathological markers of renal injury following unilateral ureteral obstruction (UUO). However, the effects of H2S on renal function following decompression is unknown. Using the UUO and reimplantation (UUO-R) model, we demonstrate that H2S accelerates the …