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Full-Text Articles in Medicine and Health Sciences
Double Dissociation Between The Effects Of Peri-Postrhinal Cortex And Hippocampal Lesions On Tests Of Object Recognition And Spatial Memory: Heterogeneity Of Function Within The Temporal Lobe., Boyer D Winters, Suzanna E Forwood, Rosemary A Cowell, Lisa M Saksida, Timothy J Bussey
Double Dissociation Between The Effects Of Peri-Postrhinal Cortex And Hippocampal Lesions On Tests Of Object Recognition And Spatial Memory: Heterogeneity Of Function Within The Temporal Lobe., Boyer D Winters, Suzanna E Forwood, Rosemary A Cowell, Lisa M Saksida, Timothy J Bussey
Brain and Mind Institute Researchers' Publications
It is widely believed that declarative memory is mediated by a medial temporal lobe memory system consisting of several distinct structures, including the hippocampus and perirhinal cortex. The strong version of this view assumes a high degree of functional homogeneity and serial organization within the medial temporal lobe, such that double dissociations between individual structures should not be possible. In the present study, we tested for a functional double dissociation between the hippocampus and peri-postrhinal cortex in a single experiment. Rats with bilateral excitotoxic lesions of either the hippocampus or peri-postrhinal cortex were assessed in tests of spatial memory (radial …
Deletion Of The Na/K-Atpase Alpha1-Subunit Gene (Atp1a1) Does Not Prevent Cavitation Of The Preimplantation Mouse Embryo., L C Barcroft, A E Moseley, J B Lingrel, A J Watson
Deletion Of The Na/K-Atpase Alpha1-Subunit Gene (Atp1a1) Does Not Prevent Cavitation Of The Preimplantation Mouse Embryo., L C Barcroft, A E Moseley, J B Lingrel, A J Watson
Obstetrics & Gynaecology Publications
Increases in Na/K-ATPase activity occur concurrently with the onset of cavitation and are associated with increases in Na(+)-pump subunit mRNA and protein expression. We have hypothesized that the alpha1-isozyme of the Na/K-ATPase is required to mediate blastocyst formation. We have tested this hypothesis by characterizing preimplantation development in mice with a targeted disruption of the Na/K-ATPase alpha1-subunit (Atp1a1) using embryos acquired from matings between Atp1a1 heterozygous mice. Mouse embryos homozygous for a null mutation in the Na/K-ATPase alpha1-subunit gene are able to undergo compaction and cavitation. These findings demonstrate that trophectoderm transport mechanisms are maintained in the absence of the …