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Swahn Southwestern Academic Health Network Conference 2017 : The Patient Voice & Experience In Southwestern Ontario, Schulich School Of Medicine & Dentistry

Department of Medicine Publications

The conference, held at Western University in London, Ontario, was a full-day event that included presentations based on its theme: The Patient Voice and Experience in Southwestern Ontario. The day began with a two-part presentation featuring Health Quality Ontario’s patient partnership framework, delivered by Jennifer Schipper, Health Quality Ontario’s Chief of Communication and Patient Engagement. Dr. Gillian Kernaghan, President and CEO of St. Joseph’s Health Care London (and Co-Chair of SWAHN) then shared her organization’s care partnership that has involved the contributions of patients, residents, families, and caregivers.

Other presentations included a personal story shared by Mr. Wayne Kristoff who …

Neurometabolic Abnormalities In Schizophrenia And Depression Observed With Magnetic Resonance Spectroscopy At 7 T, Reggie Taylor, Elizabeth A Osuch, Betsy Schaefer, Nagalingam Rajakumar, Richard W J Neufeld, Jean Theberge, Peter C Williamson

Department of Medicine Publications

BACKGROUND: Examining neurometabolic abnormalities in critical brain areas in schizophrenia and major depressive disorder (MDD) may help guide future pharmacological interventions including glutamate-modulating treatments.

AIMS: To measure metabolite concentrations within the anterior cingulate cortex (ACC) and thalamus of people with schizophrenia and people with MDD.

METHODS: Spectra were acquired from 16 volunteers with schizophrenia, 17 with MDD and 18 healthy controls using magnetic resonance spectroscopy on a 7 Tesla scanner.

RESULTS: In the thalamus, there were lower glycine concentrations in the schizophrenia group relative to control (P=0.017) and MDD groups (P=0.012), and higher glutamine concentrations relative to healthy controls (P=0.009). …

Desynchronization Of Autonomic Response And Central Autonomic Network Connectivity In Posttraumatic Stress Disorder, Janine Thome, Maria Densmore, Paul A Frewen, Margaret C Mckinnon, Jean Théberge, Andrew A Nicholson, Julian Koenig, Julian F Thayer, Ruth A Lanius

Department of Medicine Publications

OBJECTIVES: Although dysfunctional emotion regulatory capacities are increasingly recognized as contributing to posttraumatic stress disorder (PTSD), little work has sought to identify biological markers of this vulnerability. Heart rate variability (HRV) is a promising biomarker that, together with neuroimaging, may assist in gaining a deeper understanding of emotion dysregulation in PTSD. The objective of the present study was, therefore, to characterize autonomic response patterns, and their related neuronal patterns in individuals with PTSD at rest.

METHODS: PTSD patients (N = 57) and healthy controls (N = 41) underwent resting-state fMRI. Connectivity patterns of key regions within the central autonomic network …