Medicine and Health Sciences Commons^™

Data-Driven Neuroanatomical Subtypes In Various Stages Of Schizophrenia: Linking Cortical Thickness, Glutamate, And Language Functioning, Liangbing Liang

Electronic Thesis and Dissertation Repository

The considerable variation in the spatial distribution of cortical thickness changes has been used to parse heterogeneity in schizophrenia. We aimed to recover a ‘cortical impoverishment’ subgroup with widespread cortical thinning. We applied hierarchical cluster analysis to cortical thickness data of three datasets in different stages of psychosis and studied the cognitive, functional, neurochemical, language and symptom profiles of the observed subgroups. Our consensus-based clustering procedure consistently produced a subgroup characterized by significantly lower cortical thickness. This ‘cortical impoverishment’ subgroup was associated with a higher symptom burden in a clinically stable sample and higher glutamate levels with language impairments in …

Internet-Delivered Cognitive Behavioural Therapy For People With Mild Traumatic Brain Injury: A Feasibility Study, Ujjoyinee France Barua

Electronic Thesis and Dissertation Repository

Individuals with mild traumatic brain injury (mTBI) can experience high levels of emotional distress, leading to decreased quality of life and increased health care costs. Bowen's feasibility framework was used to examine the feasibility, acceptability, and limited efficacy of an innovative clinician-guided internet-delivered cognitive behavioural therapy program (ICBT) specialized for people with mTBI to improve their wellbeing. The data illustrated strong adherence and program satisfaction from participants. Likewise, statistically and clinically significant changes in symptoms of unhappiness and anxiety were found, along with improved self-efficacy and quality of life. The findings of this study contribute new knowledge to the emerging …

The Effects Of Prenatal Cannabis Exposure On The Basolateral Amygdala, Karen Kw Wong

Undergraduate Student Research Internships Conference

Clinical and preclinical studies indicate prenatal cannabis exposure (PCE) pathologically affects fetal brain development and may increase vulnerability to neuropsychiatric disorders, including schizophrenia and mood/anxiety disorders. In review research from our lab suggests that fetal exposure to Δ9-THC sex-selectively impairs mesocorticolimbic (MCL) circuit function. However, there is a distinct lack of focus on PCE models on the BLA. The BLA plays a central role within the MCL where it directly interacts with the VTA, PFC and HIPP. Importantly, our model exhibits significant VTA hyperdopaminergic activity, and sex-specific alterations to PFC/HIPP glutamate firing, alongside region- and sex-specific changes in dopamine (DA), …

The Effect Of Propionic Acid On The Habituation To Social And Non-Social Odour Cues In Adult Male Rats, Cashmeira-Dove P. Tyson

Electronic Thesis and Dissertation Repository

The enteric bacterial metabolite, propionic acid (PPA), elicits physiological and behavioural changes in rodents reminiscent of autism spectrum disorder (ASD). This includes abnormal sensory processing and social behaviour. ASD may contribute to social deficits through impaired habituation; therefore, the present study examined the effects of intraperitoneal PPA on the habituation to social and non-social odours. Adult male rats were injected daily with PPA or the vehicle control, and for 3 days, habituated to a conspecific odour or vanilla extract for 10 minutes. On day 4, rats were exposed to a novel conspecific odour or almond extract for 10 minutes to …

The Effects Of The Aromatase Inhibitor, Letrozole, On Lithium Chloride (Licl)-Induced Conditioned Disgust Behaviour (Anticipatory Nausea) In Male Rats, Vangel Matic

Undergraduate Student Research Internships Conference

Anticipatory Nausea (AN) is a form of classical conditioning in which the effects of a nausea-inducing toxin become associated with a specific environmental context. AN is often experienced by individuals receiving chemotherapy treatment, whereby the emetic effects of the chemotherapy agents become associated with the treatment context (i.e. hospital, clinic), such that exposure to the context alone can cause an individual to experience nausea and potentially withdraw from treatment. Chemotherapy-associated AN is suggested to have a higher incidence in females compared to males.

AN can be represented in a rodent model (conditioned disgust) through the occurrence of conditioned gaping behaviour …

The Experience Of Mindfulness And Its Nondual Nature In Active Practitioners, Benjamin Tran

Electronic Thesis and Dissertation Repository

Mindfulness-based interventions have become well-established in the literature as an effective treatment for various health issues. Its application in psychology is predominantly informed by dualism; however, according to its Eastern traditions, a true understanding of mindfulness is developed via nondualistic ontological experiences that emerge in a mindfulness state. The purpose of this study was to explore the experience of mindfulness and its nondual nature as it is experienced in the world. Hermeneutical phenomenology, informed by an interpretivist lens, was employed. A sample of 13 mindfulness practitioners were individually interviewed. The experience of mindfulness and its nondual nature was considered through …

Supporting Post-Secondary Implementation Of Recovery-Oriented Practice In A Stepped Care Model, Janis Campbell

The Dissertation in Practice at Western University

Student mental health has been a growing concern for higher education communities for many years. Campuses have been struggling to keep up with the increasing demand for services which has been complicated further by the COVID-19 pandemic. A Stepped Care model (SCM) developed at a Canadian university has been offering new ways of organizing mental health resources based on open access, student choice, and recovery principles. There are diverse definitions of recovery in the literature and are usually based on values such as empowerment, respect, and self-determination. SCMs have been shown to increase access to resources and reduce or eliminate …