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Full-Text Articles in Medicine and Health Sciences
Prostate Cancer Microparticles In Men Undergoing Radical Prostatectomy, Malcolm James Dewar
Prostate Cancer Microparticles In Men Undergoing Radical Prostatectomy, Malcolm James Dewar
Electronic Thesis and Dissertation Repository
Objectives: To determine changes in prostate microparticle (PMP) concentrations in men with prostate cancer (PCa) after digital rectal examination (DRE), after radical prostatectomy (RP), and at follow-up.
Materials and Methods: 22 men were recruited before RP. Four blood specimens were collected – baseline (specimen 1), post-DRE (specimen 2), immediately post-RP (specimen 3), and follow-up (specimen 4). Pre- and post-DRE urine was collected (Specimen A and B respectively). Flow cytometric analysis of biofluids was performed with fluorescent-labeled antibodies against prostate-specific membrane antigen (PSMA) and polysialic acid. Total MP (TMP) and dual positive (PMP) events per µl of plasma or urine were …
Targeted Intracellular Therapeutic Delivery Using Liposomes Formulated With Multifunctional Fast Proteins, Rae L. Nesbitt
Targeted Intracellular Therapeutic Delivery Using Liposomes Formulated With Multifunctional Fast Proteins, Rae L. Nesbitt
Electronic Thesis and Dissertation Repository
Prostate cancer is the most common malignancy in North American men and there is no treatment currently available which offers a clear survival advantage to patients with prostate cancer. We studied liposomes formulated with the fusion-associated small transmembrane (FAST) protein, p14. In this study, we hypothesized that therapeutics delivered in molecular targeted fusogenic liposomes will increase intracellular delivery and specificity for prostate cancer. We demonstrated that liposomes formulated with p14-bombesin significantly increased the delivery of fluorescein isothiocyanate (FITC) into human prostate cancer (PC-3) cells compared to either standard liposomes or non-targeted fusogenic liposomes. Delivery of FITC to benign prostate hyperplasia …
Uwomj Volume 76, No. 1, Western University
Uwomj Volume 76, No. 1, Western University
University of Western Ontario Medical Journal
Schulich School of Medicine & Dentistry