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Vestibular Stimulation Enhances Hippocampal Long-Term Potentiation Via Activation Of Cholinergic Septohippocampal Cells, Leung L. Stan
Vestibular Stimulation Enhances Hippocampal Long-Term Potentiation Via Activation Of Cholinergic Septohippocampal Cells, Leung L. Stan
Physiology and Pharmacology Publications
Vestibular stimulation induced acetylcholine release in the hippocampus, and acetylcholine is known to facilitate long-term potentiation (LTP) in the hippocampus. Thus, we hypothesize that vestibular stimulation enhances LTP in CA1 in freely behaving rats, and this enhancement depends on the activation of septohippocampal cholinergic neurons. Field excitatory postsynaptic potentials were recorded in CA1 area of behaving rats following stimulation of the basal dendritic afferents. LTP was induced by a single stimulation train (100 pulses at 200 Hz) during passive whole-body rotation or during awakeimmobility. LTP induced during rotation was significantly larger than that induced during immobility. Pretreatment with cholinergic antagonist …
Lesion Of Cholinergic Neurons In Nucleus Basalis Enhances Response To General Anesthetics, Leung L. Stan
Lesion Of Cholinergic Neurons In Nucleus Basalis Enhances Response To General Anesthetics, Leung L. Stan
Physiology and Pharmacology Publications
Acetylcholine in the brain has been associated with consciousness and general anesthesia effects. We tested the hypothesis that the integrity of the nucleus basalis magnocellularis (NBM) affects the response to general anesthetics. Cholinergic neurons in NBM were selectively lesioned by bilateral infusion of 192IgG-saporin in adult, male Long–Evans rats, and control rats were infused with saline. Depletion of choline-acetyltransferase (ChAT)-immunoreactive cells in the NBM and decrease in optical density of acetylcholinesterase (AChE) staining in the frontal and visual cortices confirmed a significant decrease in NBM cholinergic neurons in lesioned as compared to control rats. AChE staining in the hippocampus and …