Medicine and Health Sciences Commons^™

Reverting To A Healthier Diet Or Employing An Aerobic Exercise Regime Independently Restore Muscle Fiber Phenotype Disturbed By High-Fat Diet In Muscle Of Mice, Nathan Serrano, Harkaran S. Sodhi, Kailin Johnsson, Laurel B. Winslow, Layla Al-Nakkash, Christos S. Katsanos

International Journal of Exercise Science: Conference Proceedings

Obesity affects roughly 42% of the US population. High fat/high sugar diets (HFHS) often referred to as “western diet” contributes to this prevalence. Diet-induced obesity results in impaired metabolic responses and associated disease states (i.e., Type 2 Diabetes). Metabolic impairments in diet-induced obesity are a result of changes in muscle metabolism, and changes in muscle fiber phenotype, which is determined by the isoform-content of the protein myosin heavy chain (MHC). Fast muscle fiber phenotype (i.e. type IIb in mice) is characterized by lower capacity for utilization of lipids, implicated in the pathogenesis of Type 2 Diabetes. Regular exercise shifts MHC …

Estrogen Receptor Alpha Controls Mitochondrial Function And Metabolic Homeostasis, And Is Critical For Exercise-Induced Improvements In Metabolism, Alexia M. Joseph

International Journal of Exercise Science: Conference Proceedings

Skeletal muscle is an important tissue responsible for locomotion, oxidative metabolism, and insulin-stimulated glucose disposal. Because exercise is the most effective means to combat metabolic dysfunction and prevent the progression of type 2 diabetes, our laboratory is interested in understanding the molecular transducers underlying the health benefits of exercise. Previous work by our group has shown that muscle ESR1/ERα expression is correlated with indices of metabolic health, and Esr1 expression in muscle is induced following exercise training.

PURPOSE: Determine whether genetic overexpression of Esr1 to mimic transcript induction by physical activity is sufficient to produce favorable metabolic changes …