Medicine and Health Sciences Commons^™

Cerebrovascular Dysfunction And Degeneration In Alzheimer’S Disease Pathophysiology, Dominic Dimitri Quintana

Graduate Theses, Dissertations, and Problem Reports

Alzheimer’s disease (AD) is a terminal illness and the most common form of dementia, which disproportionately affects the aged population. The pathophysiology of AD is characterized by neurodegeneration that slowly progresses, affecting regions of the brain that are involved in learning, memory, language, and executive function. In patients with the disease, early symptoms include non-disruptive forgetfulness that evolves into the inability to form new memories and ultimately the loss of autonomy at late stages. Histopathological hallmarks in the brain from patients with AD is the presence of amyloid-β (Aβ)-plaques and neurofibrillary tangles (NFT) deposited in the parenchyma. Since the discovery …

Evaluation Of The Impact Of An Educational Intervention Focused On Adolescent Vaping Among Rural Middle School Students, Holly F. Fitzwater

Graduate Theses, Dissertations, and Problem Reports

According to the Centers for Disease Control (CDC), sixty deaths due to the use of electronic cigarettes or other vaping products have been reported to date. Vaping has become viewed as a safe alternative to traditional cigarette smoking, particularly in the adolescent population. The U.S. Preventive Services Task Force (USPSTF) recommends education by primary care clinicians to prevent initiation of tobacco products among adolescents. In order to combat this health disparity in America’s youth, intervention by the nursing profession is necessary. An educational session and interactive game were implemented by a school-based family nurse practitioner in order to change the …

A Phenomenological Photovoice Exploration Of Female Exercisers’ Experiences Of Their Body In Fitness Center Environments, Katherine E. Fairhurst

Graduate Theses, Dissertations, and Problem Reports

For many women, the relationship with their body and exercise is complex. Exercise can have positive effects on body image, however, not all women appear to benefit positively from all types of exercise. To date, body image research has focused on exercise as an activity and less so on the context in which exercise is performed. Women frequently exercise in fitness centers as young adults which, unfortunately, is associated with body dissatisfaction. Using an Interpretative Phenomenological Analysis (IPA) approach with Photovoice methodology, we explored young adult women’s lived body experiences while exercising in fitness centers. A purposive sample of 11 …

The Effects Of Intrinsic Foot Muscle Strengthening On Foot Posture, Balance, And Agility In Ice Hockey Players, Rebecca Eve Veltrie

Graduate Theses, Dissertations, and Problem Reports

Context: Research has shown that intrinsic foot muscle strengthening over a 4-week period is beneficial for improvements in dynamic postural control, function, stability and foot posture. Ice hockey is a sport that requires immense levels of balance, stability and performance on the lateral aspect of the skate. With research lacking on the impact of intrinsic foot muscle strengthening on ice hockey athletes’ balance, foot posture and performance, implementation of such a program may be beneficial for ice hockey players. Objective: The purpose of this study was to explore the effects of foot intrinsic muscle strengthening versus a traditional …

Three Essays On Health Economics And Policy Evaluation, Shishir Shakya

Graduate Theses, Dissertations, and Problem Reports

This dissertation consists of three essays on the U.S. Health care policy. Each paragraph below refers to the three abstracts for the three chapters in this dissertation, respectively. I provide quantitative evidence on how much Prescription Drug Monitoring Programs (PDMPs) affects the retail opioid prescribing behaviors. Using the American Community Survey (ACS), I retrieve county-level high dimensional panel data set from 2010 to 2017. I employ three separate identification strategies: difference-in-difference, double selection post-LASSO, and spatial difference-in-difference. I compare how the retail opioid prescribing behaviors of counties, that are mandatory for prescribers to check the PDMP before prescribing controlled substances …

Performance Study Of Five Different Cabin Air Filters In The Laboratory And On-Road Drive, Fahad Alqahtani

Graduate Theses, Dissertations, and Problem Reports

One of the aims of installing ventilation filters in a car is to prevent vehicle occupants from inhaling potentially harmful aerosols emanating from the environment. Vehicle cabin filters are essential in ensuring that a vehicle's air conditioning system provides clean air to its occupants. The purpose of the cabin filter is to improve air quality inside the car to provide better comfort and better protect occupants from experiencing unwanted respiratory problems. Using cabin filters in air conditioning systems is a common practice in modern vehicle manufacturing. Scientists and engineers are continually seeking new ways of improving the efficiency and effectiveness …

Accuracy Of Blx And Blt Guided Implants In The Edentulous Maxilla: An In Vivo Study, Benjamin Andrew Kordusky

Graduate Theses, Dissertations, and Problem Reports

Objectives: To determine the accuracy of dental implants placed using a dual scan CBCT protocol with a SLA 3D printed mucosa supported surgical guide using a flapless surgical approach with regard to sleeve position, type of implant, and regional location in the maxillary arch.

Methods: Nine patients received 4 dental implants utilizing a fully guided, flapless approach with a mucosa supported SLA surgical guide with 3 fixation pins. Implants were immediately loaded using an attachment placed in an existing Maxillary complete denture. Accuracy of implant positions were evaluated by the Treatment Evaluation module of coDiagnostiX (DentalWings, Montreal, Canada). Statistical analysis …

Integrating Care: Evaluation Of A Hepatitis C Clinic Co-Located With Harm Reduction And Addiction Treatment Programs In A Rural Clinic, Susan Ruth Mckenrick

Graduate Theses, Dissertations, and Problem Reports

Background: West Virginia (WV) is second in the nation for cases of Hepatitis C Virus (HCV) per capita – meaning more than 24,000 residents are living with HCV. Most new cases are in young persons who inject drugs (PWID). However, the no-call, no-show rate for HCV patients coming to clinics in Morgantown is about 50%, indicating the need to do a better job engaging them in care. Literature suggests that integrating HCV clinics with harm reduction and addiction treatment programs increases uptake of HCV treatment.

Objective: The overall objective was to establish an integrated HCV clinic where harm reduction …

Frontal Brain Injury: Effects On Flexibility, Impulse Control, And Attention, Christopher Matthew O'Hearn

Graduate Theses, Dissertations, and Problem Reports

Traumatic Brain Injury (TBI) is defined as an impact to the head, penetration of the skull, or rapid deceleration of the skull, resulting in an alteration of brain function or neurological deficit. Cognitive deficits are common following TBI and often go unresolved due to a lack of effective treatments. These deficits often perseverate into the chronic post injury phase, so the development of rehabilitative strategies is imperative. Behavioral flexibility, impulse control, and attention are a few cognitive processes that are commonly affected by TBI. The current research compares these processes between rats with and without a severe frontal brain injury …

The Visual And Spectrophotometric Effect Of External Bleaching On Omnichroma Resin Composite And Natural Teeth, Michael Brian Evans

Graduate Theses, Dissertations, and Problem Reports

Objective: To determine the visual and spectrophotometric effect external tooth bleaching has on natural tooth structure and OMNiCHROMA composite at various number of treatments. Variables were compared to determine if there is a detectable difference between the composite and the tooth before and after bleaching.

Methods: Preparation and restoration of 25 previously extracted teeth was completed. OMNiCHROMA composite was used. Each tooth was measured visually with a VITA shade guide and a colorimeter. Measurements were recorded before bleaching, after 5 and 10 treatments. Statistical analysis was completed and ΔE values between the composite and tooth were compared between the 3 …

Clear Aligner Therapy Vs. Traditional Brackets On Smile Arc, Sarah Elizabeth Larue

Graduate Theses, Dissertations, and Problem Reports

Background and Objectives: More so than ever, the public is becoming exceedingly aware of esthetics, and will evaluate their treatment outcome based upon the improvement to their smile and overall enhancement of their facial appearance. Smile arc is considered to be a key component of facial esthetics. Literature has demonstrated that orthodontic treatment mechanics utilizing traditional brackets and wires can cause flattening of the smile arc and that smiles with flatter arcs are judged to be less attractive. The aim of this study was to determine whether clear aligner therapy can help to preserve or improve the smile arc …

Evaluation Of The Impact Of An Educational Intervention Aimed At Improving Tuberculosis Infection Control Knowledge Among Health Care Workers In A Military Treatment Facility: A Quality Improvement Project, Allen C. Potter

Graduate Theses, Dissertations, and Problem Reports

Background: Florida (FL) is one of the top five states in the nation for Tuberculosis (TB) infections. A majority of new infections can be found in the minority populations which represents 78% of all TB infections in the state. A combination of TB rates in FL, Orlando located 60 miles away and a transient population who frequently deploys worldwide to austere locations may result in an increased risk of acquiring TB. Literature suggests Health Care Providers (HCPs) obtain training regarding TB Infection Control (TB-IC). The Patrick AFB Military Treatment Facility (MTF) lacked a TB Infection Control (TB-IC) plan. Objective: The …

Evaluation Of The Care And Communication Bundle To Improve Palliative Care In Intensive Care Units, Angela Susan Bohon

Graduate Theses, Dissertations, and Problem Reports

Review of local data and concerns from nursing staff revealed the need to improve palliative care in a local, community hospital Intensive Care Unit (ICU). This effort was mobilized by implementing the Care and Communication Bundle within evidence-based time frames, into this local, community ICU, using Lewin’s Change theory as a guide for implementation. The Care and Communication Bundle is a grouping of nine palliative, quality measures found to improve palliative care in the ICU. A pre/post-educational intervention evaluated if the implementation of the Care and Communication Bundle in the ICU improved palliative care by reviewing the documentation of the …

Evidence Of Y Chromosome Long Non-Coding Rnas Involved In The Radiation Response Of Male Non-Small Cell Lung Cancer Cells, Tayvia Brownmiller

Graduate Theses, Dissertations, and Problem Reports

Non-small cell lung cancer (NSCLC) is the number one cause of cancer related mortality in the United States and worldwide. Advanced and therapeutically resistant lung tumors contribute to the high rate of mortality from NSCLC, therefore there is a need for new methods of diagnosing and treating this disease. Long non-coding RNAs (lncRNAs) have been shown to be a crucial component of human molecular biology, regulating nearly every cellular pathway from chromatin condensation to transcription and translation. Furthermore, many lncRNAs have been classified as oncogenes or tumor suppressors, highlighting the various molecular mechanisms they are involved in regarding the formation …

Association Of Common Chronic Pain Conditions To Incident Alzheimer’S Disease And Related Dementias In Two Cohorts Of Older Medicare Beneficiaries, Sumaira Khalid

Graduate Theses, Dissertations, and Problem Reports

Objective: The purpose of this research was to study the collective and incremental association of common non-cancer chronic pain conditions (NCPC) to risk for Alzheimer’s disease and related dementias (ADRD); to explore the potential mediating influence of mood and sleep disorders; and to assess the potential synergistic effects of NCPC’s and multimorbidity on ADRD risk. This research also aimed to study the contribution of NCPC to ADRD risk in poor, rural, underserved United States populations who suffer a disproportionate burden of ADRD risk factors. To achieve these goals, this dissertation pursued three specific aims: 1) assess the association of …

Pulmonary Immune Responses To Respirable Elongate Mineral Particles Of Asbestiform And Non-Asbestiform Morphologies, Timur Khaliullin

Graduate Theses, Dissertations, and Problem Reports

Inhalation exposure to asbestiform elongate mineral particles (EMPs) may cause pulmonary fibrosis, lung and pleural cancer. At the same time, epidemiological evidence for non-asbestiform EMP pathogenicity is scarce, with little if any risk of cancer, but consistent findings of pneumoconiosis and increased mortality. Globally, conditions caused by asbestos exposures contribute most to the occupational cancer burden and are responsible for the increasing mortality for occupational respiratory diseases. Immunological components of the fiber-induced lesions are extremely understudied, partly due to the lack of comparable test articles. In this study I utilized respirable preparations of asbestiform and non-asbestiform riebeckite and tremolite to …

Structural Transformations Of Synaptic Partners During Growth And Competition Of The Giant Nerve Terminal, The Calyx Of Held, In The Medial Nucleus Of The Trapezoid Body In The Developing Postnatal Mouse, Dakota Richard Jackson

Graduate Theses, Dissertations, and Problem Reports

Across many parts of the nervous system, initial neural circuit assembly involves stereotyped stages of early axonal proliferation within target territories, selective reinforcement of a subset of inputs and the removal of exuberant or unneeded connections via either activity or experience-dependent mechanisms, in a process referred to as synaptic competition. The mechanisms and associated structural transformations that underlie and define these stages of neurodevelopment have been examined in a variety of brain regions including the peripheral neuromuscular junction, the central climbing fiber innervation of cerebellar Purkinje cells and retinal ganglion cell innervation of the thalamic lateral geniculate nucleus. Each of …

Wv Dental Hygienists' Knowledge And Educational Approach For Pregnant Women, Isabella Hope Mcdaniel

Graduate Theses, Dissertations, and Problem Reports

Background: Adverse pregnancy outcomes have become a concern for dental professionals caring for pregnant women with poor oral health. Pregnant women may not be aware of their increased risk of bacterial infections in their oral tissues and how it could relate to adverse pregnancy outcomes such as pre- term birth (PTB) and low birthweight babies (LBW). Dental healthcare professionals need to be well informed of risk related to poor oral health and have confidence to effectively educate pregnant women. PTB and LBW babies account for 1 million infant deaths annually. It is the responsibility of dental healthcare professionals to be …

Quality Improvement Of Substance Misuse Screening Of Older Adults In Primary Care Using Evidence-Based Training, Kelly Lopez

Graduate Theses, Dissertations, and Problem Reports

Background

The largest increase in preventable overdose deaths from 1999-2017 occurred among adults 50 and older, yet substance misuse among older adults is often not screened for or recognized in primary care settings. This oversight has been attributed to many factors, including age-related biases, unrecognized psychosocial and physiological differences, stigmatization, and a rapidly growing geriatric population.

Objectives

A quality improvement program using evidence-based educational training was implemented in a primary care setting with the intention to expand care knowledge and ultimately improve screening practices of older adults, especially those suffering from substance misuse.

Design

This quality improvement (QI) project used …

Environmental Contaminants, Parasitism, And Neoplasia In White Perch Morone Americana From Chesapeake Bay, Usa, Mark Arnold Matsche

Graduate Theses, Dissertations, and Problem Reports

White perch are an abundant demersal fish species in freshwater and oligohaline habitats of the Chesapeake Bay. An avoidance of salinity > 12-15 ppt generally restricts the distribution and movements of fish to within tributaries in the mid to lower Bay, which over time has resulted in the formation of at least three separate stocks in Chesapeake Bay. Sub-populations of white perch that are partially isolated may serve as sentinels of the conditions or stressors in the tributaries in which they reside. Fish are exposed to a variety of environmental contaminants and other anthropogenic stressors that can vary in magnitude based …

Creating A Community-Based Protocol To Prevent Unintended Pregnancy In Homeless Women In Monongalia County, West Virginia, Jessica Eva Wukasch

Graduate Theses, Dissertations, and Problem Reports

Background: At any given time, 10% of homeless women are pregnant, about twice the rate of all U.S. women of reproductive age (5%) (Healthcare for the Homeless, 2001). According to Healthcare for the Homeless Council ([HHC], 2012), approximately “73% of pregnancies among homeless women were unintended at the time of conception.” In addition, “about 12% of homeless children are placed in foster care compared to 1% of other children” (HHC, 2012). There is an evident need to address unintended pregnancy among homeless women.

Objective: The overall objective was to create an accessible and useful community-based protocol to reduce the rate …

Applications Of Machine Learning Methods In Health Outcomes Research: Heart Failure In Women, Khalid Abdullah Alhussain

Graduate Theses, Dissertations, and Problem Reports

There is robust evidence that heart failure (HF) is associated with substantial mortality, morbidity, poor health-related quality of life, healthcare utilization, and economic burden. Previous research has revealed that there are sex differences in the epidemiology, etiology, and disease burden of HF. However, research on HF among women, especially postmenopausal women, is limited. To fill the knowledge gap, the three related aims of this dissertation were to: (1) identify knowledge gaps in HF research among women, especially postmenopausal women, using unsupervised machine learning methods and big data (i.e., articles published in PubMed); (2) identify emerging predictors (i.e., polypharmacy and some …

The 2014 West Virginia Elk River Chemical Leak: A Case Study Of Respiratory Health Disparities And Drinking Water Contamination, Maya Nye

Graduate Theses, Dissertations, and Problem Reports

This case study supplements existing data with original analysis to address environmental pollution burden and health effects not previously examined from the 2014 Freedom Industries Elk River chemical leak in West Virginia. Comparisons were made between the peer-reviewed literature, governmental disaster management practices implemented during the leak, and alternative human health assessment models to determine whether the evidence relied upon for decision-making was adequate for protecting public health, minimizing health disparities and increasing health equity. An emphasis was placed on understanding how the state and federal government approached human health hazard assessment and health outcome reporting, particularly of socially vulnerable …

The Use Of Differing Verb Types In The Oral Narratives Of School-Age Children, Allison Ann Switzer

Graduate Theses, Dissertations, and Problem Reports

The aim of this project was to examine the use of action, metacognitive, and metalinguistic verbs in narratives relative to age-related growth for children with typical language and their peers with a language-based disorder. While limited information is known about the use of these differing verb types, there is evidence to show that metacognitive and metalinguistic verbs are less salient than action verbs, and therefore have a longer trajectory of acquisition. The oral narratives of 84 typically developing students were coded for occurrences of action verbs, metacognitive verbs, and metalinguistic verbs to obtain a total use as well as to …

Tobacco Cessation In A Dental School Setting, Kerri T. Simpson

Graduate Theses, Dissertations, and Problem Reports

Introduction

Tobacco use remains the single largest preventable cause of death in the United States. Currently, the prevalence of tobacco use is 20.7% in adults (≥18 years old) and 31.2% among high school students. According to various studies, over 60% of Americans want to quit tobacco, but it takes a person several attempts to quit before they are successful. There is limited data in the literature that discusses the effectiveness of tobacco cessation programs in US dental schools. Therefore, information on the effectiveness of a tobacco cessation program in a dental school setting could benefit this state and the problem …

Injury-Related Infant Mortality In West Virginia, 2010-2014, Wilson A. Koech

Graduate Theses, Dissertations, and Problem Reports

Background and objective

Infant mortality in United States is high relative to other more developed nations. Therefore, there is a need to curb this trend, especially in states with high infant mortality rates. Hence, this research investigated and examined characteristics associated with injury-related infant death in West Virginia. The objective of this retrospective study was to 1) investigate maternal and infant characteristics associated with injury-related infant deaths in West Virginia, 2) examine the relationship between unintentional-injury-related infant death and rurality in West Virginia, holding other variables in the model constant, and 3) compare differences in the unintentional-injury related infant mortality …

The Effects Of Acute Photobiomodulation On Anaerobic Exercise Performance, Jillian Danielle Forsey

Graduate Theses, Dissertations, and Problem Reports

Optimal performance in sport requires a balance between training stress and recovery. Therapeutic modalities that allow athletes to maintain this balance while training hard are in high demand, but many lack research. Photobiomodulation is a red and near-infrared light therapy that is proposed to enhance exercise performance and hasten recovery. The purpose of this study was to examine the effects of acute whole body photobiomodulation, applied pre-exercise, on anaerobic exercise performance.

Forty-eight healthy, active subjects participated in this single-blind, crossover study. Subjects visited the lab three times to complete a repeat Wingate test, with one week between each visit. All …

Breaking The Chain: Evaluating The Links Between Opioid Use Disorder, Overdose, And Suicide, Amanda Nicole Stover Mph

Graduate Theses, Dissertations, and Problem Reports

Previous research has estimated that 20–30% of individuals with opioid use disorder (OUD) have a history of both suicide attempt and unintentional opioid overdose. In 2018, more than 1.9 million adults 18 years and older had an OUD; while 1.4 million adults attempted suicide that same year (SAMHSA, 2019). The key to understanding this relationship is examining behaviors that precede these potentially fatal behaviors. One such precursory behavior is self-injury. Self-injurious behaviors (SIB) are one of the most important risk factors for future suicide (Cavanagh et al.,2003). This study has three primary objectives. The first is to conduct a systematic …

Retrospective Evaluation Of The Changes In The Nasal And Pharyngeal Airway Volume After Miniscrew Assisted Rapid Palatal Expansion (Marpe) Appliance, Joanna Song

Graduate Theses, Dissertations, and Problem Reports

Background and Objectives: A transverse deficiency of the maxilla is a pervasive skeletal problem that can affect almost a quarter of the primary dentition population. The interesting relationship between rapid maxillary expansion (RME) and its effects on the surrounding airway is not well described in the literature. For today’s contemporary orthodontist, there are a variety of rapid palatal expanders (RPE) and expansion protocols to prescribe for patient treatment. Of late, the miniscrew-assisted RPE (MARPE) has been receiving attention by clinicians because of its increased orthopedic effects when compared to conventional RPE while avoiding the surgical procedure needed with SARPE. …

Changing Dynamics Of Opioid Overdoses In West Virginia And Impact Of Medication For Opioid Use Disorder And Recurrence Of Overdose On Reducing Mortality Among West Virginia Medicaid Beneficiaries, Zheng Dai

Graduate Theses, Dissertations, and Problem Reports

Background

With increasing number of opioid overdoses in West Virginia (WV) in recent years and limited number of people receiving treatment, the dissertation study aims to better understand fatal overdose problems in WV and the impact of medication for opioid use disorder (MOUD) in preventing overdose deaths.

Method

WV drug-related deaths from 2005 to 2018 was used to describe the involvement of fentanyl and FAs. WV Medicaid claim data was analyzed to describe the recurrent opioid overdose and the changes in receipt of MOUD. Further, a Medicaid opioid overdose cohort was created to evaluate the effect of occurrence of recurrent …