Medicine and Health Sciences Commons^™

Cerebrovascular Dysfunction With Stress And Depression, Emily Burrage, Kent L. Marshall, Nalini Santanam, Paul D. Chantler

Clinical and Translational Science Institute

Maintenance of adequate tissue perfusion through a dense network of cerebral microvessels is critical for the perseveration of normal brain function. Regulation of the cerebral blood flow has to ensure adequate delivery of nutrients and oxygen with moment-to-moment adjustments to avoid both hypo- and hyper-perfusion of the brain tissue. Even mild impairments of cerebral blood flow regulation can have significant implications on brain function. Evidence suggests that chronic stress and depression elicits multifaceted functional impairments to the cerebral microcirculation, which plays a critical role in brain health and the pathogenesis of stress-related cognitive impairment and cerebrovascular events. Identifying the functional …

Treatment For Depression And Health-Related Quality Of Life Among Adults With Arthritis, Drishti Shah, Pragya Rai, Nilanjana Dwibedi, Usha Sambamoorthi

Clinical and Translational Science Institute

Depression treatment has been proven to relieve depressive symptoms and pain and may therefore improve the health-related quality of life (HRQoL) among adults with arthritis. The objective of the current study was to examine the HRQoL associated with depression treatment among adults with arthritis and depression. A retrospective longitudinal cohort study design using data from the Medical Expenditure Panel Survey (2009–2012) was adopted. The study sample consisted of adults (≥21 years) with co-existing arthritis and depression (N = 1692). Depression treatment was categorized into: antidepressants only, psychotherapy with or without antidepressants, and neither antidepressants nor psychotherapy. Multivariable Ordinary Least Square …

Community-Deliverable Exercise And Depression In Adults With Arthritis: Confirmatory Evidence Of A Meta-Analysis Using The Ivhet Model, George A. Kelley, Kristi S. Kelley

Clinical and Translational Science Institute

Objective—Using the traditional random-effects model, a recently reported standardized effect size (g) reduction of −0.42 (95% CI, −0.58 to −0.27) was observed as a result of communitydeliverable exercise in adults with arthritis and other rheumatic diseases (AORD). However, a recently proposed alternative model (IVhet) has been shown to have superior coverage probability to the random-effects model. The purpose of this brief report was to compare these previous random-effects results with the IVhet model. Methods—Based on a previous meta-analysis of 35 g’s representing 2,449 participants, results were pooled using the IVhet model. Influence analysis, number needed-to-treat (NNT), percentile improvement, and gross …

Masculine Traits And Depressive Symptoms In Older And Younger Men And Women, Elizabeth C. Price, Jeffrey J. Gregg, Merideth D. Smith, Amy Fiske

Faculty & Staff Scholarship

Evidence suggests that men who strongly endorse masculine traits display an atypical presentation of depression, including more externalizing symptoms (e.g., anger or substance use), but fewer typical, internalizing symptoms (e.g., depressed mood or crying). This phenomenon has not been adequately explored in older adults or women. The current study used the externalizing subscale of the Masculine Depression Scale in older and younger men and women to detect atypical symptoms. It was predicted that individuals who more strongly endorsed masculine traits would have higher scores on the measure of externalizing symptoms relative to a measure of typical depressive symptoms Center for …

Depression Treatment Decreases Healthcare Expenditures Among Working Age Patients With Comorbid Conditions And Type 2 Diabetes Mellitus Along With Newly-Diagnosed Depression, Rituparna Bhattacharya, Chan Shen, Amy B. Wachholtz, Nilanjana Dwibedi, Usha Sambamoorthi

Faculty & Staff Scholarship

Background: There are many studies in the literature on the association between depression treatment and health expenditures. However, there is a knowledge gap in examining this relationship taking into account coexisting chronic conditions among patients with diabetes. We aim to analyze the association between depression treatment and healthcare expenditures among adults with Type 2 Diabetes Mellitus (T2DM) and newly-diagnosed depression, with consideration of coexisting chronic physical conditions.

Methods: We used multi-state Medicaid data (2000–2008) and adopted a retrospective longitudinal cohort design. Medical conditions were identified using diagnosis codes (ICD-9-CM and CPT systems). Healthcare expenditures were aggregated for each month for …