Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Synergistic Effect Of Black Tea Polyphenol, Theaflavin-3,3'-Digallate With Cisplatin Against Cisplatin Resistant Human Ovarian Cancer Cells, Haibo Pan, Jin Li, Gary O. Rankin, Yon Rojanasakul, Youying Tu, Yi Charlie Chen
Synergistic Effect Of Black Tea Polyphenol, Theaflavin-3,3'-Digallate With Cisplatin Against Cisplatin Resistant Human Ovarian Cancer Cells, Haibo Pan, Jin Li, Gary O. Rankin, Yon Rojanasakul, Youying Tu, Yi Charlie Chen
Clinical and Translational Science Institute
Theaflavin-3, 3’-digallate (TF3) is a phenolic compound extracted from black tea. We previously demonstrated that TF3 selectively inhibited ovarian cancer cells. Ovarian cancer has high death rate because of acquired cisplatin resistance. We aimed to investigate the synergistic effect of TF3 and cisplatin (CDDP) against cisplatin resistant ovarian cancer cells. In the present study, combination treatment with TF3 and CDDP showed a synergistic cytotoxic effect in A2780/CP70 and OVCAR3 cells. Combination treatment showed a synergistic pro-apoptotic effect and synergistically induced G1/S phase cell cycle arrest. Synergistic apoptosis was accompanied by regulating protein expression of cleaved caspase 3/7, cytochrome c, Bax …
Anti-Proliferation Effect Of Theasaponin E₁ On The Aldh-Positive Ovarian Cancer Stem-Like Cells, Ling-Yan Jia, Hui-Long Xia, Zhi-Da Chen, Casey Compton, Heather Bucur, Devendra A. Sawant, Gary O. Rankin, Bo Li, You-Ying Tu, Yi Charlie Chen
Anti-Proliferation Effect Of Theasaponin E₁ On The Aldh-Positive Ovarian Cancer Stem-Like Cells, Ling-Yan Jia, Hui-Long Xia, Zhi-Da Chen, Casey Compton, Heather Bucur, Devendra A. Sawant, Gary O. Rankin, Bo Li, You-Ying Tu, Yi Charlie Chen
Clinical and Translational Science Institute
Ovarian cancer has the highest mortality rate of all gynecological malignancies and the five-year death rate of patients has remained high in the past five decades. Recently, with the rise of cancer stem cells (CSCs) theory, an increasing amount of research has suggested that CSCs give rise to tumor recurrence and metastasis. Theasaponin E1 (TSE1), which was isolated from green tea (Camellia sinensis) seeds, has been proposed to be an effective compound for tumor treatment. However, studies on whether TSE1 takes effect through CSCs have rarely been reported. In this paper, ALDH-positive (ALDH+) ovarian cancer stem-like cells from two platinum-resistant …
Theaflavin-3,3'- Digallate Enhances The Inhibitory Effect Of Cisplatin By Regulating The Copper Transporter 1 And Glutathione In Human Ovarian Cancer Cells, Haibo Pan, Eunhye Kim, Gary O. Rankin, Yon Rojanasakul, Youying Tu, Yi Charlie Chen
Theaflavin-3,3'- Digallate Enhances The Inhibitory Effect Of Cisplatin By Regulating The Copper Transporter 1 And Glutathione In Human Ovarian Cancer Cells, Haibo Pan, Eunhye Kim, Gary O. Rankin, Yon Rojanasakul, Youying Tu, Yi Charlie Chen
Clinical and Translational Science Institute
Ovarian cancer has the highest fatality rate among the gynecologic cancers. The side effects, high relapse rate, and drug resistance lead to low long-term survival rate (less than 40%) of patients with advanced ovarian cancer. Theaflavin-3,3′-digallate (TF3), a black tea polyphenol, showed less cytotoxicity to normal ovarian cells than ovarian cancer cells. We aimed to investigate whether TF3 could potentiate the inhibitory effect of cisplatin against human ovarian cancer cell lines. In the present study, combined treatment with TF3 and cisplatin showed a synergistic cytotoxicity against A2780/CP70 and OVCAR3 cells. Treatment with TF3 could increase the intracellular accumulation of platinum …
Dietary Compound Proanthocyanidins From Chinese Bayberry (Myrica Rubra Sieb. Et Zucc.) Leaves Inhibit Angiogenesis And Regulate Cell Cycle Of Cisplatin-Resistant Ovarian Cancer Cells Via Targeting Akt Pathway, Yu Zhang, Shiguo Chen, Chaoyang Wei, Gary O. Rankin, Yon Rojanasakul, Ning Ren, Xingqian Ye, Yi Charlie Chen
Dietary Compound Proanthocyanidins From Chinese Bayberry (Myrica Rubra Sieb. Et Zucc.) Leaves Inhibit Angiogenesis And Regulate Cell Cycle Of Cisplatin-Resistant Ovarian Cancer Cells Via Targeting Akt Pathway, Yu Zhang, Shiguo Chen, Chaoyang Wei, Gary O. Rankin, Yon Rojanasakul, Ning Ren, Xingqian Ye, Yi Charlie Chen
Clinical and Translational Science Institute
Ovarian cancer is the leading cause of death from gynecological malignancy and natural products have drawn great attention for cancer treatment. Chinese bayberry leaves proanthocyanidin (BLPs) with epigallocatechin-3-O-gallate (EGCG) as its terminal and major extension units is unusual in the plant kingdom. In the present study, BLPs showed strong growth inhibitory effects on cisplatin-resistant A2780/CP70 cells by inhibiting angiogenesis and inducing G1 cell cycle arrest. BLPs reduced the tube formation in HUVECs and attenuated the wound healing ability in A2780/CP70 cells. BLPs further reduced the level of ROS and targeted Akt/mTOR/p70S6K/4E-BP-1 pathway to reduce the expression of HIF-1α and VEGF, …
Theaflavin-3,3′-Digallate Enhances The Inhibitory Effect Of Cisplatin By Regulating The Copper Transporter 1 And Glutathione In Human Ovarian Cancer Cells, Haibo Pan, Eunhye Kim, Gary O. Rankin, Yon Rojanasakul, Youying Tu, Yi Charlie Chen
Theaflavin-3,3′-Digallate Enhances The Inhibitory Effect Of Cisplatin By Regulating The Copper Transporter 1 And Glutathione In Human Ovarian Cancer Cells, Haibo Pan, Eunhye Kim, Gary O. Rankin, Yon Rojanasakul, Youying Tu, Yi Charlie Chen
Faculty & Staff Scholarship
Ovarian cancer has the highest fatality rate among the gynecologic cancers. The side effects, high relapse rate, and drug resistance lead to low long-term survival rate (less than 40%) of patients with advanced ovarian cancer. Theaflavin-3,3′-digallate (TF3), a black tea polyphenol, showed less cytotoxicity to normal ovarian cells than ovarian cancer cells. We aimed to investigate whether TF3 could potentiate the inhibitory effect of cisplatin against human ovarian cancer cell lines. In the present study, combined treatment with TF3 and cisplatin showed a synergistic cytotoxicity against A2780/CP70 and OVCAR3 cells. Treatment with TF3 could increase the intracellular accumulation of platinum …