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In Vitro Inflammatory Effects Of Hard Metal (Wc–Co) Nanoparticle Exposure, Andrea L. Armstead, Bingyun Li
In Vitro Inflammatory Effects Of Hard Metal (Wc–Co) Nanoparticle Exposure, Andrea L. Armstead, Bingyun Li
Faculty & Staff Scholarship
Identifying the toxicity of nanoparticles (NPs) is an important area of research as the number of nanomaterial-based consumer and industrial products continually rises. In addition, the potential inflammatory effects resulting from pulmonary NP exposure are emerging as an important aspect of nanotoxicity. In this study, the toxicity and inflammatory state resulting from tungsten carbide–cobalt (WC–Co) NP exposure in macrophages and a coculture (CC) of lung epithelial cells (BEAS-2B) and macrophages (THP-1) at a 3:1 ratio were examined. It was found that the toxicity of nano-WC–Co was cell dependent; significantly less toxicity was observed in THP-1 cells compared to BEAS-2B cells. …
In Vitro Inflammatory Effects Of Hard Metal (Wc-Co) Nanoparticle Exposure, Andrea L. Armstead, Bingyun Li
In Vitro Inflammatory Effects Of Hard Metal (Wc-Co) Nanoparticle Exposure, Andrea L. Armstead, Bingyun Li
Faculty & Staff Scholarship
Identifying the toxicity of nanoparticles (NPs) is an important area of research as the number of nanomaterial-based consumer and industrial products continually rises. In addition, the potential inflammatory effects resulting from pulmonary NP exposure are emerging as an important aspect of nanotoxicity. In this study, the toxicity and inflammatory state resulting from tungsten carbide–cobalt (WC–Co) NP exposure in macrophages and a coculture (CC) of lung epithelial cells (BEAS-2B) and macrophages (THP-1) at a 3:1 ratio were examined. It was found that the toxicity of nano-WC–Co was cell dependent; significantly less toxicity was observed in THP-1 cells compared to BEAS-2B cells. …