Medicine and Health Sciences Commons^™

Hypertrophy-Promoting Effects Of Leucine Supplementation And Moderate Intensity Aerobic Exercise In Pre-Senescent Mice, Zhi Xia, Jason Cholewa, Yan Zhao, Yue-Qin Yang, Hua-Yu Shang, Lucas Guimaraes-Ferreira, Marshall Alan Naimo, Quan-Sheng Su, Nelo Eidy Zanchi

Faculty & Staff Scholarship

Several studies have indicated a positive influence of leucine supplementation and aerobic training on the aging skeletal muscle signaling pathways that control muscle protein balance and muscle remodeling. However, the effect of a combined intervention requires further clarification. Thirteen month old CD-1® mice were subjected to moderate aerobic exercise (45 min swimming per day with 3% body weight workload) and fed a chow diet with 5% leucine or 3.4% alanine for 8 weeks. Serum and plasma were prepared for glucose, urea nitrogen, insulin and amino acid profile analysis. The white gastrocnemius muscles were used for determination of muscle size and …