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Articles 1 - 16 of 16
Full-Text Articles in Medicine and Health Sciences
Neuroanatomy Of The Subadult And Fetal Brain Of The Atlantic White-Sided Dolphin (Lagenorhynchus Acutus) From In Situ Magnetic Resonance Images, Eric W. Montie, Gerald E. Schneider, Darlene R. Ketten, Lori Marino, Katie E. Touhey, Mark E. Hahn
Neuroanatomy Of The Subadult And Fetal Brain Of The Atlantic White-Sided Dolphin (Lagenorhynchus Acutus) From In Situ Magnetic Resonance Images, Eric W. Montie, Gerald E. Schneider, Darlene R. Ketten, Lori Marino, Katie E. Touhey, Mark E. Hahn
Veterinary Science and Medicine Collection
This article provides the first anatomically labeled, magnetic resonance imaging (MRI) -based atlas of the subadult and fetal Atlantic white-sided dolphin (Lagenorhynchus acutus) brain. It differs from previous MRI-based atlases of cetaceans in that it was created from images of fresh, postmortem brains in situ rather than extracted, formalin-fixed brains. The in situ images displayed the classic hallmarks of odontocete brains: fore-shortened orbital lobes and pronounced temporal width. Olfactory structures were absent and auditory regions (e.g., temporal lobes and inferior colliculi) were enlarged. In the subadult and fetal postmortem MRI scans, the hippocampus was identifiable, despite the relatively small size …
Considerations For Determining Optimal Mouse Caging Density, Charmaine Foltz, Larry Carbone, David Delong, Bernard E. Rollin, Pascalle Van Loo, Julia Whitaker, Axel Wolff
Considerations For Determining Optimal Mouse Caging Density, Charmaine Foltz, Larry Carbone, David Delong, Bernard E. Rollin, Pascalle Van Loo, Julia Whitaker, Axel Wolff
Laboratory Research and Animal Welfare Collection
At the 2006 National Meeting of the American Association of Laboratory Animal Science, a panel discussed the question of what constitutes optimal or acceptable housing density for mice. Though there is a consensus that present guidelines are somewhat arbitrarily defined, scientific research has not yet been able to provide clear recommendations for amending them. Speakers explored the many factors that influence decisions on mouse housing, including regulatory requirements, scientific data and their interpretation, financial considerations and ethical concerns. The panel largely agreed that animal well-being should be the measure of interest in evaluating housing density and that well-being includes not …
The Development Of New Concepts For Assessing Reproductive Toxicity Applicable To Large Scale Toxicological Programmes, S. Bremer, C. Pellizzer, S. Hoffmann, T. Seidle, T. Hartung
The Development Of New Concepts For Assessing Reproductive Toxicity Applicable To Large Scale Toxicological Programmes, S. Bremer, C. Pellizzer, S. Hoffmann, T. Seidle, T. Hartung
Experimentation Collection
Large scale toxicological testing programmes which are currently ongoing such as the new European chemical legislation REACH require the development of new integrated testing strategies rather than applying traditional testing schemes to thousands of chemicals. The current practice of requiring in vivo testing for every possible adverse effect endanger the success of these programmes due (i) to limited testing facilities and sufficient capacity of scientific/technical knowledge for reproductive toxicity; (ii) an unacceptable number of laboratory animals involved (iii) an intolerable number of chemicals classified as false positive.
A key aspect of the implementation of new testing strategies is the determination …
Nociception In Fish: Stimulus–Response Properties Of Receptors On The Head Of Trout Oncorhynchus Mykiss, Paul J. Ashley, Lynne U. Sneddon, Catherine R. Mccrohan
Nociception In Fish: Stimulus–Response Properties Of Receptors On The Head Of Trout Oncorhynchus Mykiss, Paul J. Ashley, Lynne U. Sneddon, Catherine R. Mccrohan
Veterinary Science and Medicine Collection
This study examined stimulus–response properties of somatosensory receptors on the head of rainbow trout, Oncorhynchus mykiss, using extracellular recording from single cells in the trigeminal ganglion. Of 121 receptors recorded from 39 fish, 17 were polymodal nociceptors, 22 were mechanothermal nociceptors, 18 were mechanochemical receptors, 33 were fast adapting mechanical receptors and 31 were slowly adapting mechanical receptors. Mechanical thresholds were higher in polymodal nociceptors than in either slowly adapting or fast adapting mechanical receptors, whereas thermal thresholds of mechanothermal nociceptors were higher than those of polymodal nociceptors. Polymodal nociceptors and mechanochemical receptors gave similar responses to topical applications of …
Ethical Issues In Geriatric Feline Medicine, Bernard E. Rollin
Ethical Issues In Geriatric Feline Medicine, Bernard E. Rollin
Veterinary Science and Medicine Collection
Most veterinarians hold a ‘pediatric’ rather than ‘garage mechanic’ view of their function. In recent years, sophisticated medical modalities have allowed veterinarians to keep animals alive, and increased value of companion animals in society has increased demand for such treatment. But whereas humans can choose to trade current suffering for extended life, animals seem to lack the cognitive apparatus required to do so. Thus, veterinarians must guard against keeping a suffering animal alive for too long. Clients may be emotionally tied to the animal and blind to its suffering. Part of the veterinarian’s role, therefore, is to lead the client …
The Veterinary Profession’S Duty Of Care In Response To Disasters And Food Animal Emergencies, Kenneth E. Nusbaum, Bernard E. Rollin, James S. Wohl
The Veterinary Profession’S Duty Of Care In Response To Disasters And Food Animal Emergencies, Kenneth E. Nusbaum, Bernard E. Rollin, James S. Wohl
Professional Veterinary Ethics Collection
No abstract provided.
Cetacean Brains: How Aquatic Are They?, Lori Marino
Cetacean Brains: How Aquatic Are They?, Lori Marino
Anatomy Collection
The adaptation of cetaceans to a fully aquatic lifestyle represents one of the most dramatic transformations in mammalian evolutionary history. Two of the most salient features of modern cetaceans are their fully aquatic lifestyle and their large brains. This review article will offer an overview of comparative neuroanatomical research on aquatic mammals, including analyses of odontocete cetacean, sirenian, pinniped, and fossil archaeocete brains. In particular, the question of whether a relationship exists between being fully aquatic and having a large brain is addressed. It has been hypothesized that the large, well‐developed cetacean brain is a direct product of adaptation to …
Animal Research: A Moral Science, Bernard E. Rollin
Animal Research: A Moral Science, Bernard E. Rollin
Experimentation Collection
No abstract provided.
Cetaceans Have Complex Brains For Complex Cognition, Lori Marino, Richard C. Connor, R. Ewan Fordyce, Louis M. Herman, Patrick R. Hof, Louis Lefebvre, David Lusseau, Brenda Mccowan, Esther A. Nimchinsky, Adam A. Pack, Luke Rendell, Joy S. Reidenberg, Diana Reiss, Mark D. Uhen, Estel Van Der Gucht, Hal Whitehead
Cetaceans Have Complex Brains For Complex Cognition, Lori Marino, Richard C. Connor, R. Ewan Fordyce, Louis M. Herman, Patrick R. Hof, Louis Lefebvre, David Lusseau, Brenda Mccowan, Esther A. Nimchinsky, Adam A. Pack, Luke Rendell, Joy S. Reidenberg, Diana Reiss, Mark D. Uhen, Estel Van Der Gucht, Hal Whitehead
Anatomy Collection
We believe that the time is ripe to present an integrated view of cetacean brains, behavior, and evolution based on the wealth of accumulated and recent data on these topics. Our conclusions support the more generally accepted view that the large brain of cetaceans evolved to support complex cognitive abilities.
Dolphin-Assisted Therapy: More Flawed Data And More Flawed Conclusions, Lori Marino, Scott O. Lilienfeld
Dolphin-Assisted Therapy: More Flawed Data And More Flawed Conclusions, Lori Marino, Scott O. Lilienfeld
Animal-Assisted Therapy Collection
Dolphin-Assisted Therapy (DAT) is an increasingly popular choice of treatment for illness and developmental disabilities by providing participants with the opportunity to swim or interact with live captive dolphins. Two reviews of DAT (Marino and Lilienfeld [1998] and Humphries [2003]) concluded that there is no credible scientific evidence for the effectiveness of this intervention. In this paper, we offer an update of the methodological status of DAT by reviewing five peer-reviewed DAT studies published in the last eight years. We found that all five studies were methodologically flawed and plagued by several threats to both internal and construct validity. We …
The Human/Animal Interface: Emergence And Resurgence Of Zoonotic Infectious Diseases, Michael Greger
The Human/Animal Interface: Emergence And Resurgence Of Zoonotic Infectious Diseases, Michael Greger
Transgenesis Collection
Emerging infectious diseases, most of which are considered zoonotic in origin, continue to exact a significant toll on society. The origins of major human infectious diseases are reviewed and the factors underlying disease emergence explored. Anthropogenic changes, largely in land use and agriculture, are implicated in the apparent increased frequency of emergence and reemergence of zoonoses in recent decades. Special emphasis is placed on the pathogen with likely the greatest zoonotic potential, influenzavirus A.
Chimpanzee Research: An Examination Of Its Contribution To Biomedical Knowledge And Efficacy In Combating Human Diseases, Jarrod Bailey, Jonathan Balcombe, Theodora Capaldo
Chimpanzee Research: An Examination Of Its Contribution To Biomedical Knowledge And Efficacy In Combating Human Diseases, Jarrod Bailey, Jonathan Balcombe, Theodora Capaldo
Experimentation Collection
Research on captive chimpanzees incurs considerable animal welfare, ethical and financial costs. Advocates of such research claim these costs are outweighed by substantial advancements in biomedical knowledge, and that the genetic similarity of chimpanzees to humans enables the former to make critical contributions to preventing, diagnosing and combating human diseases. To assess these claims, we examined the disciplines investigated in 749 studies of captive chimpanzees published from 1995-2004 inclusive, and subjected 95 randomly selected papers to a detailed citation analysis:
49.5% (47/95) of papers had not been cited at the time of this study; 38.5% (34/95) were cited by 116 …
Their Bugs Are Worse Than Their Bite: Emerging Infectious Disease And The Human-Animal Interface, Michael Greger
Their Bugs Are Worse Than Their Bite: Emerging Infectious Disease And The Human-Animal Interface, Michael Greger
State of the Animals 2007
In the twenty-five years since that announcement, what we now know as AIDS has killed 20 million people (National AIDS Trust 2005). Where did the AIDS virus— and other emerging diseases, such as severe acute respiratory syndrome (SARS), Ebola, mad cow— come from?
An Hsus Report: Human Health Implications Of U.S. Live Bird Markets In The Spread Of Avian Influenza, The Humane Society Of The United States
An Hsus Report: Human Health Implications Of U.S. Live Bird Markets In The Spread Of Avian Influenza, The Humane Society Of The United States
Impact of Animal Agriculture
After millions of years of existing as a harmless infection of aquatic birds, some strains of avian flu have developed the ability to mutate into highly pathogenic forms that may not only be deadly for birds, but potentially more dangerous for humans as well. Experts from the World Health Organization, the World Organization for Animal Health, and the Food and Agriculture Organization of the United Nations have joined leading scientists in implicating industrialized poultry production for providing fertile ground for the transformation of benign bird flu into highly pathogenic strains.
Live bird markets can be the conduit by which waterfowl …
Of Mice And Men, Bernard E. Rollin
A Holistic Approach To Taking Research Animal Suffering Seriously, Martin Stephens, Kathleen Conlee
A Holistic Approach To Taking Research Animal Suffering Seriously, Martin Stephens, Kathleen Conlee
Experimentation Collection
It is widely agreed, and often legally required, that distress and pain in research animals should be minimized--for the sake of animal welfare, ethical obligation, and public concern, as well as scientific quality. As testimony to the importance of distress and pain to stakeholders interested in research animals, many countries compile and publish annual statistics documenting overall patterns and trends on distress and pain in research animals.
We argue for a holistic approach to minimizing research animal suffering, with all relevant parties sharing in this responsibility. Researchers, laboratory personnel, oversight committees, and facility administrators are central to day-to-day animal care. …