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Full-Text Articles in Medicine and Health Sciences
Axogial Communication Mediated By Soluble Neuregulin-1 And Bdnf, Zhenzhong Ma
Axogial Communication Mediated By Soluble Neuregulin-1 And Bdnf, Zhenzhong Ma
Wayne State University Dissertations
During peripheral nervous system development, successful communication between axons and glial cells including Schwann cells in peripheral nervous system and oligodendrocytes in central nervous system, is required for the proper functions of both neurons and glia. Three types of alternatively-spliced proteins belonging to the neuregulin1 (NRG1) gene family of growth and differentiation factors are essential for Schwann cell survival and peripheral nerve development. While membrane-bound NRG1 forms (type III) has been strongly implicated in the regulation of myelination process at late stage of Schwann cell development, little is known about the role of soluble, heparin-binding forms of NRG1 (type I/II) …
Analysis Of Gaba And Glutamate In The Mouse Dorsal Striatum, Stella Wisidagamage
Analysis Of Gaba And Glutamate In The Mouse Dorsal Striatum, Stella Wisidagamage
Wayne State University Theses
ABSTRACT
ANALYSIS OF GABA AND GLUTAMATE IN MICE BRAIN
by
STELLA WISIDAGAMA
May 2011
Advisor: Dr. Tiffany Mathews
Major: Chemistry (Analytical)
Degree: Master of Science
GABA and glutamate are the predominant inhibitory and excitatory amino acid neurotransmitters in the central nervous system (CNS), respectively. However, their altered levels cause several neurological diseases including Parkinson's and Huntington's disease, schizophrenia, and epilepsy. It is important to measure their levels in the extra- and intracellular environments to better understand and develop improved therapeutics that will treat these neurological disorders. The principle aim of this study is to study the impacts of different endogenous …