Medicine and Health Sciences Commons^™

Introducing A Trauma-Informed Care Model To Address Racial Disparities In Perinatal Outcomes Among African American Women, Mariah K. White

Honors College Theses

Racial disparities in maternal and infant health have remained an issue within the United States despite efforts to advance and improve our health system. Most maternal deaths are preventable, especially with early and adequate maternal care. Infant mortality occurs for several reasons, but inadequate care usage increases the risk for adverse outcomes. Prenatal care usage within the United States has been inadequate for numerous years, most commonly among African American women, despite its known benefit. Low prenatal care usage among African American women can be attributed to community barriers, social injustices, trauma, discrimination, and health care mistrust. Trauma is common …

Social Media And Wellbeing, Aditya Adsule

Honors College Theses

This psychology thesis paper investigates the existing body of scientific literature surrounding the effects of social media on the wellbeing of adolescents and adults ages 18-29. The current body of scientific literature supports the overall finding that social media has a negative impact not only on mental health, but on physical health. There are also key findings showing the impact of social media on other facets of life such as sleep patterns, social interactions, and physical activity. Current intervention therapies need to be revisited and the DSM categorization of social media addiction needs to be investigated further.

Infrastructure And Policies Supporting Physical Activity Habits: A Comparison Between The United States And Europe, Anisha Laddha

Honors College Theses

Most adults in the United States are not getting enough physical activity, and this is causing high rates of adverse health conditions such as diabetes and cardiovascular disease in the population. The rising costs of cardiovascular disease are a national problem that must be tackled from multiple perspectives. This literature review explores policies and infrastructure implemented in European countries with better health outcomes and higher physical activity levels in the population compared to the United States. The infrastructure in places such as Germany and Denmark is constructed to encourage physical activity in the form of active transportation such as walking …

The Importance Of Protein Context In Spinocerebellar Ataxia Type 3, Sean Luis Johnson

Wayne State University Dissertations

Spinocerebellar Ataxia Type 3 (SCA3) is a member of the family of polyglutamine (polyQ) neurodegenerative disorders that includes Huntington's Disease and several other SCAs. SCA3, the most common dominant ataxia in the world, is caused by polyQ tract expansion in the protein, ataxin-3. How SCA3 occurs and how to treat it remain unresolved issues. The primary culprit of toxicity in all polyQ diseases is the glutamine repeat: its abnormal expansion leads to neuronal dysfunction and death. With that said, there is indisputable evidence that the way polyQ-dependent toxicity presents—areas impacted, cellular processes perturbed—is predicated in large part on regions outside …

Novel Interaction Of Cxcr4 And Pi4kiiiα In Prostate Cancer, Barani Govindarajan

Wayne State University Dissertations

The CXCR4-CXCL12 chemokine signaling axis plays a key role in migration and bone metastasis in prostate cancer (PC). Androgens regulate CXCR4 expression and its receptor activation in lipid-raft micro domains of PC cells, resulting in higher protease expression and invasion. In order to identify some novel CXCR4 co-regulators associated within the lipid-raft, a SILAC (Stable isotope labeling using amino acid in cell culture)-based proteomic analysis was performed with PC3 stable cell-lines over-expressing or knocking-down CXCR4. Phosphatidylinositol 4-kinase III alpha (PI4KIIIα or PI4KA) and SAC1 lipid phosphatase were identified as candidate proteins enriched in CXCR4 expressing cells. PI4KA is an evolutionarily …

Backward Walking: A Novel Marker Of Fall Risk, Cognitive Dysfunction, And Myelin Damage In Persons With Multiple Sclerosis, Erin Edwards

Wayne State University Dissertations

Multiple sclerosis (MS) is a progressive, neurologic disease of the central nervous system that causes debilitating motor, sensory and cognitive impairments. As a result, persons with MS are at an increased risk for falls and falls represent a serious public health concern for the MS population. The current clinical measures used to assess fall risk in MS patients lack sensitivity and predictive validity for falls and are limited in their ability to capture to multiple functional domains (i.e., motor, sensory, cognitive and pathological domains) that are impaired by MS. Backward walking sensitively detects falls in the elderly and other neurologic …

Hearing And Other Factors Influencing Memory Performance In Remote Assessment, Erika Squires

Wayne State University Dissertations

With the revitalization of aural rehabilitation (AR) and increased use of telepractice services, there is a paucity of research examining factors that have the potential to affect remote assessment. An assessment of memory is commonly included in a comprehensive AR assessment because recently developed auditory-cognitive training programs include auditory-based cognitive activities, such as auditory memory tasks. This investigation explored the effect of presentation modality on speech discrimination performance and whether self-reported hearing ability correlated with remote memory assessment in older adults.Older adults self-reported their hearing abilities and completed speech discrimination and memory tasks. Data were collected remotely via a telephone …

The Lived Experiences Of Muslim Women With Infertility, Samia Abdelnabi

Wayne State University Dissertations

Background: Infertility, ranked as the 5th highest global disability, is estimated to impact 180 million couples worldwide. Muslim couples associate parenthood or the ability to have children as an accomplishment in their marriage, adulthood, social status, and security in later life. A failure to conceive in Muslim societies may lead to stigma, social isolation, grief, and despair. There is a gap in the literature on how Muslim women perceive, understand, and cope with infertility in the U.S. This knowledge gap limits the ability in to understand how social, religious, and cultural practices impact a diagnosis of infertility on Muslim American …

Roles Of A Bradykinin Storm And A Cytokine Storm In Covid-19 Cases, Nouha H. Odeh

Honors College Theses

In the light of recent events, it is imperative to understand the key inflammatory response elements that appear to be the source of more severe ailments resulting from a SARS-CoV-2 viral infection known as Covid-19 The more severe cases of Covid-19 are characterized by a severe inflammatory response resulting in tissue damage. My research proposal aims to investigate the two possible culprits of this response: a bradykinin (BK) storm and an interleukin-6 (IL-6) mediated cytokine storm. In both systems respectively, the excess release of these signals subsequently signals the production of even more of the same response element, resulting in …

Abhd5 Induced Morphological Changes On Model Membrane Systems, Nasser S. Junedi

Honors College Theses

Proper regulation of neutral lipid storage (lipogenesis) and release (lipolysis) are critical molecular processes localized to an organelle called the Lipid Droplet (LD). The LD consists of a core with neutral lipids such as triacylglycerols (TAGs) and sterol esters surrounded by a phospholipid monolayer. Dysregulation of the processes localized to the LD are involved in the pathology of various diseases such as Neutral Lipid Storage Disease, diabetes, stroke and cancer. The non-enzymatic protein ABHD5 (α-β Hydrolase Domain-Containing Protein 5), is thought to play a key role in the process of lipolysis by forming homo-oligomers on the surface of the LD …

S.O.S. For Covid-19 (Subjective And Objective Screening): Are Asymptomatic Cases Truly Without Warning Signs?, Nathan Hughes

Honors College Theses

This study investigates the usefulness of five objective signs, evaluates relationships between objective signs with symptoms of COVID-19, and assesses the accuracy of ambient forehead temperature with tympanic temperature. Data were collected at Wayne State University. Blood oxygen levels and blood pressure were measured via pulse oximeters and blood pressure cuff. Body temperature was measured with a thermometer via the temple and the forehead. Smell was tested with two scented markers. None of the 29 participants confirmed a positive COVID-19 test. Therefore, only relationships between vital sign measurements were reported. No significant correlations were revealed upon analysis. Infrared and temporal …

Oral Cbd Administration: Assessing Bioavailability And Behavioral Outcomes In A Rodent Model, Jordan Skully

Wayne State University Theses

There has been a recent surge in popularity for cannabidiol (CBD), a major non-psychotropic constituent of cannabis, due to numerous claims of potential therapeutic properties, which include, but are not limited to, anxiolytic, antinociceptive, and anti-inflammatory effects. However, as previous scientific literature on CBD's effectiveness in providing such therapeutic effects is limited, this project was aimed to evaluate the potential beneficial properties of a hemp derived 99% pure CBD compound provided from Ellipse Analytics (Denver, CO) in a rodent model. We analyzed the pharmacokinetics of this CBD product as well as the behavioral outcomes after acute and chronic administration. Pharmacokinetics …

Clinical Significance, Functional Role And Molecular Mechanism Of 2’-O-Methyltransferase Ftsj3 In Promoting Cancer Progression, Morenci Manning-Powell

Wayne State University Dissertations

2’-O-methylation (2’-O-Me), one of the most common modifications within RNA, has multiple roles in modulating RNA structure, stability, and interactions, as well as gene transcription and translation. We previously performed integrative genomic and transcriptomic analysis of 58 RNA methyltransferases, and identified FTSJ3 (FtsJ RNA 2ʹ-O-methyltransferase 3) as significantly amplified/overexpressed in breast cancer. Knockdown of FTSJ3 inhibits breast cancer cell growth in vitro. However, the clinical significance, functional role, and molecular mechanism of FTSJ3 in human cancer remains to be elucidated. In the present study, we first analyzed the differential mRNA and protein expression of FTSJ3 between tumor and normal tissues …

Modulation Of Pharyngeal Health In Bacterial Diet-Dependent Survival, Deniz Sifoglu

Wayne State University Dissertations

ABSTRACT

MODULATION OF PHARYNGEAL HEALTH IN BACTERIAL DIET-DEPENDENT SURVIVAL

by

DENIZ SIFOGLU

August 2021

Advisor: Dr. Joy Alcedo Major: Biological Sciences Degree: Doctor of Philosophy Both diet and bacterial microbiome modulate insulin signaling, which regulates key physiological processes that are important for survival. However, the mechanisms through which diet and the microbiome modulate insulin signaling remain unclear. To understand these mechanisms, I turned to the nematode worm C. elegans, whose diet consists of different types of bacteria. Like humans and other animals, C. elegans has to modulate its responses to its diet and to bacteria to optimize its survival. Because …

Language Concordance In Medicine And The Need For Medical Schools To Require Taking A Foreign Language As An Intervention Method To Minimize Language Barriers In The U.S., Mary K. Yousif

Honors College Theses

During medical school future student doctors are exposed to a multitude of patients, both natives and non-natives. However, there is no course offering (such as a foreign language or culture class) provided within the curriculum that prepares them for these future interactions. With communication being one of the primary skills used in healthcare, it is imperative to discuss the effects it can cause on a patient if not established. Overall, the goal of this research is to conduct a literary investigation regarding this matter and educate the medical community about the importance of providing effective communication in medicine. This begins …

Internal Training Load In Collegiate Basketball Players: Effort Ratings Vs. Heart Rate Measurements In Ncaa Dii Players, Amber Stephens

Honors College Theses

BACKGROUND: College basketball is an intense team sport that utilizes both the aerobic and anaerobic energy systems to play a 40-minute-long game and cover around 2-3 miles on average per game (Narazaki et al 2009). The high workloads can lead to fatigue, which increases injury risk (Garbenytė-Apolinskienė et al 2019). The purpose of this study is to compare subject ratings of perceived exertion (RPE) with objective measures of heart rate during pre-season training.

METHODS: Male and female basketball players from a National Collegiate Athletic Association (NCAA) Division II school wore a heart rate monitor (Firstbeat™) during the first …

Caffeine’S Physiological And Psychological Effects, Cameron Shadaia

Honors College Theses

In my university honors research paper, I will not only take a look at the physiological and psychological effects of the body, but also the proper range of caffeine intake, the situational purposes for caffeine, the best and worst ways to introduce caffeine into the body, and popular beverages that are commonly used for caffeine consumption. This research paper draws upon a variety of studies in which caffeine was the topic of interest. The conclusion that is drawn upon is that caffeine can have many benefits if used in a proper dosage. Negative effects have a higher likelihood of occurring …

The Implementation Of Exercise For Chronic Kidney Disease And Dialysis Patients, Syed Ahmad Rizvi

Honors College Theses

While commonly known to be the organ that helps with urine production within the human body, the kidney plays one of the most crucial roles in maintaining homeostasis. When establishing all of the roles the kidney has on keeping humans healthy, there is the question of how does the body cope when a patient is diagnosed with kidney failure. One of the more common treatment options that allows the body to continue to function without a kidney is by beginning a patient on a form of dialysis. However, as with any treatment, there will always be a list of side …

Evaluating Historical Paradigms Of Sterility In Perinatal Microbiology And Ramifications For Pregnancy Outcomes, Jonathan Greenberg

Wayne State University Dissertations

Next-generation sequencing technologies, especially 16S rRNA gene and metagenomic sequencing have allowed investigations of low microbial biomass tissues of the human body. While these sequencing methodologies have provided large amounts of reliable data for higher microbial biomass sites, such as the mouth, intestine, and vagina, tissues of low microbial biomass sites are subject to specific caveats that were not appropriately considered in early investigations of these sites. Low microbial biomass sites of particular interest have included those of the reproductive and urinary systems. Utilization of DNA sequencing methodologies have allowed researchers to challenge existing paradigms of sterility around these sites …

Investigation Of Physiochemical Properties And Biocompatibility Of Amourphos Calcium Polyphosphate Hydrogel Doped With Antibiotics And Injectable Polymeric Dicalcium Phosphate Dihydrate Bone Cement, Yasaman Chehreghanianzabi

Wayne State University Dissertations

Amorphous calcium polyphosphate (ACPP) is an inorganic polymer ceramic. Here we use a simple method of preparing ACPP hydrogel in the presence of excess volume of water. Essentially, water availability to polyphosphate chains accelerates water molecule ingress and microstructural transformation of ACPP hydrogels. Antibiotic delivery capacity of ACPP hydrogel increases by the specific mixing and molding method, where the VCM has higher antibiotic encapsulation efficiency with the small burst release for the compressed discs. In part of this study, we investigate impact of ACPP hydrogel replacement by monomeric calcium phosphate on the quality of final product (dicalcium phosphate dihydrates (DCPD) …

Determinants Of Successful Diabetes Self-Management Behaviors Among Women Of Arab Descent With Type 2 Diabetes, Mona R. Alanzi

Wayne State University Dissertations

ABSTRACT

Type 2 Diabetes (T2D) continues to be an escalating public health problem that contributes to increased morbidity and mortality worldwide (American Diabetes Association, 2017b). According to the National Diabetes Statistics Report (2017), approximately 30.3 million (9.4%) Americans have T2D. It accounted for 252,806 deaths in 2015 in the United States. Although the complications of T2D is a major threat to the health of women of Arab descent, there is lack of information about the health practices and diabetes self-management behaviors of this population. The purpose of this dissertation is to examine the impact of diabetes knowledge, social/family support, acculturation, …

Nutrition And Health Status Of Hemodialysis Patients In Dhaka, Bangladesh, Tanjina Rahman

Wayne State University Dissertations

Methods to identify patients at risk for End stage renal disease (ESRD) are a high priority in Bangladesh, where kidney transplants/dialysis options are limited and costly. Every year, 35,000 to 40,000 people reach ESRD in Bangladesh, but currently available facilities can hardly accommodate only 9000 to 10,000 new patients with twice weekly dialysis and the remaining 66% have no access to any kind of renal replacement therapy (RRT) in the form of dialysis or transplantation. Nutrition is an important factor in maintaining good health of hemodialysis patients. However, data on nutritional status of Bangladeshi dialysis patients is limited and is …

Mental Health Service Utilization Among Urban Adolescents: The Roles Of Perceived Mental Health Problems, Attitudes Towards Professional Help, And Stigma, Yi Tak Tsang

Wayne State University Dissertations

Mental health among adolescents is widely acknowledged as a significant concern in the United States. Based on a national survey, Merikangas et al. (2010) found that among 13-17 year olds, 42% to 48% reported experiencing mental health concerns. It is estimated that only half of adolescents with mental health problems utilize mental health services (Costello et al., 2014). An initial study found that caregivers of disadvantaged youth appeared to function as the “gatekeepers” to mental health services (Tsang et al., 2020). Also, the results suggested that positive attitude towards professional psychological help, but not stigma, predicted service enrollment. The current …

Age Differences In Hippocampal Glutamate Modulation During Associative Learning And Memory: A Proton Functional Magnetic Resonance Spectroscopy (1h Fmrs) Study, Chaitali Anand

Wayne State University Dissertations

Episodic and associative memory decline is one of the earliest cognitive impairments in normal aging and among the defining cognitive features of Alzheimer’s disease (AD). Since, age-related cognitive decline gradually devolves into AD, with neuropathology preceding cognitive changes by many years, the identification of biomarkers of early disease progression is crucial. Reduction in glutamate, the main excitatory neurotransmitter involved in associative memory, in key brain regions such as the hippocampus, has been theorized as one of the cellular mechanisms underlying cognitive decline in aging and AD. A few neuroimaging studies that demonstrated a link between older adults’ weaker cognitive performance …

Hormonal Regulation Of Glycine Decarboxylase And Its Metabolic Outcomes, Ruta Milind Jog

Wayne State University Dissertations

The amino acid glycine is involved in generation of multiple critical metabolites including glutathione, heme, and creatinine. Interestingly, in both humans and rodents, circulating glycine levels are significantly reduced in obesity, glucose intolerance, type II diabetes and non-alcoholic fatty liver disease. The glycine cleavage system is the predominant glycine degradation pathway in humans. The rate-limiting enzyme of glycine cleavage system is glycine decarboxylase (GLDC), and loss-of-function mutations of GLDC cause hyperglycinemia. Here, we show that GLDC gene expression is upregulated in livers of mouse models of diabetes and diet-induced obesity as well as in the fasted state in normal animals. …

Pilot Evaluation Of The Computer-Based Assessment Of Non-Cognitive Attributes Of Health Professionals (Cana-Hp), Sara Faye Maher

Wayne State University Dissertations

To meet the needs of complex and/or underserved patient populations, health care professionals must possess diverse backgrounds, qualities, and skill sets. Holistic review has been used to diversify student admissions through examination of non-cognitive attributes of health care applicants. The objective of this study was to develop a novel methodology, the computer-based assessment of non-cognitive attributes of health professionals (CANA­ HP), to effectively screen non-cognitive attributes of applicants. Three research questions were delineated; 1.) To determine the CANA-HP instrument reliability (internal consistency & interrater), 2.) To determine if the CANA-HP measured attributes of non­cognitive variables, as demonstrated by low construct …

The Effects Of Postpartum Depression, Acculturative Stress, And Social Support On Mother-Infant Bonding Among U.S. Immigrant Women Of Arabic Descent, Darin Mansor Mathkor

Wayne State University Dissertations

Purpose and Background/Significance: The transition from “woman” to “mother” is a significant life event and can be extremely stressful when merged with the transition from ‘local’ to ‘immigrant’. The development of mother-infant bonding is considered a critical process in the postpartum period. Immigrant women have higher rates of PPD compared with women in their native countries. Among the general population, PPD is strongly associated with lower quality mother-infant bonding. Social support can play a central role in lowering the levels of PPD, and may contribute to higher quality of mother-infant bonding. Moreover, limited data suggests that acculturative stress is found …

Dynamic Resource Allocation For Coordination Of Inpatient Operations In Hospitals, Najibesadat Sadatijafarkalaei

Wayne State University Dissertations

Healthcare systems face difficult challenges such as increasing complexity of processes, inefficient utilization of resources, high pressure to enhance the quality of care and services, and the need to balance and coordinate the staff workload. Therefore, the need for effective and efficient processes of delivering healthcare services increases. Data-driven approaches, including operations research and predictive modeling, can help overcome these challenges and improve the performance of health systems in terms of quality, cost, patient health outcomes and satisfaction.

Hospitals are a key component of healthcare systems with many scarce resources such as caregivers (nurses, physicians) and expensive facilities/equipment. Most hospital …

Parametric Study Of Short Latency Vestibular Evoked Potentials In Healthy Young Adults, Sabahet Fatima Rizvi

Wayne State University Dissertations

The purpose of this study was to evaluate the feasibility of developing a novel approach of otolith assessment in humans. This approach used vestibular short-latency evoked potentials (VsEP) to evaluate some fundamental characteristics of VsEP responses in healthy young adults. Currently, measures for direct assessment of the otoliths are non-existent, as vestibular evoked myogenic potentials (VEMPs) rely on neck muscle contraction for cVEMPs or are a reflection of the vestibulo-ocular reflex (VOR) for oVEMPs, rather than the otoliths themselves (Fujimoto, Suzuki, Kinoshita, Egami, Sugasawa, & Iwasaki, 2018).

Stimuli consisted of bone-conducted vibrations elicited by a specialized vibrator (Bruel & Kjaer, …

Investigating Gray And White Matter Microstructure In Parkinson Disease Patients Using Diffusion Weighted Imaging, Wafaa Sweidan

Wayne State University Dissertations

Parkinson disease (PD) is a neurodegenerative disorder characterized histologically by the loss of dopaminergic neurons in the substantia nigra (SN), and clinically by motor symptoms. PD pathology extends beyond the SN, and involves the presence of intraneuronal inclusions in neuronal bodies (Lewy bodies) and dendrites (Lewy dendrites). A staging system for Lewy pathology has been proposed, where it is hypothesized that the disease initiates in the peripheral nerves system and spreads along a caudal-rostral pathway to the brain stem and the cerebral cortex. Histological and imaging studies highlight a role for cortical Lewy pathology and atrophy, respectively, in mediating the …