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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Role Of Integrase-Pp2a Interaction In Human T-Cell Leukemia Virus Type-1 Replication And Pathogenesis, Shayna Turbin
Role Of Integrase-Pp2a Interaction In Human T-Cell Leukemia Virus Type-1 Replication And Pathogenesis, Shayna Turbin
Senior Honors Papers / Undergraduate Theses
Human T-cell leukemia virus type-1 (HTLV-1) is an oncogenic retrovirus that causes multiple disorders, including adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 retroviral integrase binds to the regulatory B’56γ subunit of the host cell Protein Phosphatase 2A (PP2A). Integrase contains a highly conserved LxxIxE motif that is essential for binding, which increases integration efficiency and facilitates HTLV-1 hijack of host cell machinery. We aim to understand how mutations introduced in the highly conserved binding site can affect viral particle production and infectivity. We transfected 729B human lymphoblastoid cells and 293T cells with mutant and wildtype virus. Mutations L213A, …
Radical Support: Understanding Doula Work As Resistance To Routinized Violence, Arianna Parkhideh
Radical Support: Understanding Doula Work As Resistance To Routinized Violence, Arianna Parkhideh
Senior Honors Papers / Undergraduate Theses
Continuous support during labor has been demonstrated to have positive effects on maternal and infant health, as well as improving birth experiences. The benefits of doula support are particularly important for improving the maternal and infant health outcomes for Black pregnant individuals and others facing health inequities. The role of doulas in addressing the Black maternal health crisis motivates this study of the underlying mechanisms through which doulas support clients and operate within hospital settings to create positive outcomes. An online survey was used to understand the perspectives of doulas on the Black maternal health crisis and the strategies they …
Investigating Localization And Activity-Dependent Translation Of Astrocyte Mrna, Rohan Khazanchi
Investigating Localization And Activity-Dependent Translation Of Astrocyte Mrna, Rohan Khazanchi
Senior Honors Papers / Undergraduate Theses
Over the past two and a half years, I have studied fundamental aspects of astrocyte biology by investigating the existence and mechanism of astrocyte local translation peripherally around tripartite synapses consisting of pre- and post-synaptic neuron terminals and an associated astrocyte. Astrocytes are critical components of central nervous system synapses (which are predominately tripartite in nature); thus, it is important to consider how astrocyte dysregulation and dysfunction could contribute to the pathogenesis of diseases of synaptic connectivity such as autism spectrum disorders, Alzheimer’s disease, seizure disorders, and more. Overall, my projects involved the development of novel methods to identify astrocyte-specific …
Conceiving Of Contraception: St. Louis Women's Perspectives On Family Planning & Contraception, Priya Suri
Conceiving Of Contraception: St. Louis Women's Perspectives On Family Planning & Contraception, Priya Suri
Senior Honors Papers / Undergraduate Theses
This work highlights the stories women weave as they make their contraceptive decisions. It included their perceptions regarding cultural, religious, and economic barriers. Fifty-one women were interviewed using a semi-structured interview style of about thirty-eight questions in the South Grand St. Louis Planned Parenthood. Contraception itself was primarily thought of as a scientific technology; however, in the context of family planning, it took on social meanings that reflected preparedness in life, financial security, religious viewpoints and the ability to choose. Women expressed varying levels of religious influence. Discussing how each woman understands her own relationship with religion, God, and/or her …