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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Cellular Mechanisms By Which Alcohol Promotes Hiv Protease Inhibitor-Induced Hepatotoxicity, Michael Hinton
Cellular Mechanisms By Which Alcohol Promotes Hiv Protease Inhibitor-Induced Hepatotoxicity, Michael Hinton
Theses and Dissertations
CELLULAR MECHANISMS BY WHICH ALCOHOL PROMOTES HIV PROTEASE INHIBITOR-INDUCED HEPATOTOXICITY
Michael Hinton, B.S.
A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University
Virginia Commonwealth University, 2019
Major Director: Huiping Zhou
Professor, Department of Microbiology and Immunology
The development of highly-active-antiretroviral therapy(HAART) has allowed management of HIV and extended the lives of those infected. Alcohol abuse, which is very common in HIV-1 infected patients, is one of the most important co-morbid risk factors for liver injury and has been associated with the occurrence of serious metabolic syndrome and subsequent discontinuation …
Evaluation Of A New Trauma-Related Drinking To Cope Measure: Latent Structure And Heritability, Sage E. Hawn, Steven H. Aggen, Danielle Dick, Ananda B. Amstadter Phd
Evaluation Of A New Trauma-Related Drinking To Cope Measure: Latent Structure And Heritability, Sage E. Hawn, Steven H. Aggen, Danielle Dick, Ananda B. Amstadter Phd
Graduate Research Posters
Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) commonly co-occur, share latent genetic risk, and are associated with many negative public health outcomes. Via a self-medication framework, trauma-related drinking to cope (TRD), an unexplored phenotype to date, may help explain why these two disorders co-occur, thus serving as an essential target for treatment and prevention efforts. This study sought to create a novel measure of TRD and to investigate its indirect influences on the association between PTSD and AUD, as well as its potential shared molecular genetic risk with PTSD in a genetically-informative study of college students. A sample …
Genome-Wide Systems Genetics Of Alcohol Consumption And Dependence, Kristin Mignogna
Genome-Wide Systems Genetics Of Alcohol Consumption And Dependence, Kristin Mignogna
Theses and Dissertations
Widely effective treatment for alcohol use disorder is not yet available, because the exact biological mechanisms that underlie this disorder are not completely understood. One way to gain a better understanding of these mechanisms is to examine the genetic frameworks that contribute to the risk for developing this disorder. This dissertation examines genetic association data in combination with gene expression networks in the brain to identify functional groups of genes associated with alcohol consumption and dependence.
The first study took advantage of the behavioral complexity of human samples, and experimental capabilities provided by mouse models, by co-analyzing gene expression networks …