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Full-Text Articles in Medicine and Health Sciences
Differential Reactivity Of Microglia In Two Mouse Models Of Multiple Sclerosis, Rebecca K. Hartley
Differential Reactivity Of Microglia In Two Mouse Models Of Multiple Sclerosis, Rebecca K. Hartley
Theses and Dissertations
Multiple sclerosis (MS) is a neurodegenerative disorder characterized by CNS inflammation and axonal demyelination. In addition, axonal pathology has also been reported in MS and may be responsible for the functional deficits associated with this disease. Based on preliminary data from our laboratory, we propose that a specific domain of the neuron, known as the axon initial segment (AIS), is targeted in MS. Consistent with our work from the human tissue, we have also observed disruption of AIS integrity in a murine CNS inflammatory model and observations strongly implicate reactive microglia as mediators of AIS disruption. In contrast, a murine …
Resolution Of Inflammation Rescues Axon Initial Segment Disruption, Nicholas M. George
Resolution Of Inflammation Rescues Axon Initial Segment Disruption, Nicholas M. George
Theses and Dissertations
Axonal domains are required for proper neuron function. These domains are unstable and degenerate concurrent with the inflammation in multiple sclerosis (MS) and the inflammatory disease models experimental autoimmune encephalomyelitis (EAE) and lipopolysaccharide (LPS) induced inflammation. Previous studies from our laboratory have shown that the axon initial segment (AIS) is maintained independently of the presence of myelin, but that AIS disruption is seen in MS as well as EAE and LPS-mediated inflammation. AIS loss can be interrupted in the early stage of EAE using the anti-inflammatory drug Didox. However, the potential for Didox directed repair of the AIS in later …