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Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
Effect Of Ceftazidime On Systemic Cytokine Concentrations In Rats, Khalid M. Alkharfy, John A. Kellum, Reginald F. Frye, Gary R. Matzke
Effect Of Ceftazidime On Systemic Cytokine Concentrations In Rats, Khalid M. Alkharfy, John A. Kellum, Reginald F. Frye, Gary R. Matzke
Pharmacotherapy and Outcomes Science Publications
The effect of a single dose of ceftazidime on circulating concentrations of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in a rat model of sepsis was studied. IL-6 concentrations were significantly elevated (100 to 200 times the baseline) 6 h after ceftazidime administration in both septic and nonseptic (control) rats. TNF-α concentrations increased significantly in nonseptic (∼40 times the baseline) rats but not septic (∼2 to 3 times the baseline) rats. Ceftazidime administration was not associated with an increase in endotoxin concentrations. These findings suggest that ceftazidime modulation of proinflammatory cytokine concentrations may be independent of its antimicrobial properties.
The Phantom Burster Model For Pancreatic Β-Cells, Richard Bertram, Joseph Previte, Arthur Sherman, Tracie A. Kinard, Leslie S. Satin
The Phantom Burster Model For Pancreatic Β-Cells, Richard Bertram, Joseph Previte, Arthur Sherman, Tracie A. Kinard, Leslie S. Satin
Pharmacology and Toxicology Publications
Abstract
Pancreatic β-cells exhibit bursting oscillations with a wide range of periods. Whereas periods in isolated cells are generally either a few seconds or a few minutes, in intact islets of Langerhans they are intermediate (10–60 s). We develop a mathematical model for β-cell electrical activity capable of generating this wide range of bursting oscillations. Unlike previous models, bursting is driven by the interaction of two slow processes, one with a relatively small time constant (1–5 s) and the other with a much larger time constant (1–2 min). Bursting on the intermediate time scale is generated without need …
Determinants Of Ceftazidime Clearance By Continuous Venovenous Hemofiltration And Continuous Venovenous Hemodialysis, Gary R. Matzke, Reginald F. Frye, Melanie S. Joy, Paul M. Palevsky
Determinants Of Ceftazidime Clearance By Continuous Venovenous Hemofiltration And Continuous Venovenous Hemodialysis, Gary R. Matzke, Reginald F. Frye, Melanie S. Joy, Paul M. Palevsky
Pharmacotherapy and Outcomes Science Publications
Although several dosage adjustment regimens have been proposed, there is little quantitative information to guide the initiation of ceftazidime therapy in patients who are receiving continuous renal replacement therapy. To determine the clearance of ceftazidime by continuous venovenous hemofiltration (CVVH) and continuous venovenous hemodialysis (CVVHD), we performed controlled clearance studies with stable hemodialysis patients with three hemofilters: a 0.6-m2 acrylonitrile copolymer (AN69; Hospal) filter, a 2.1-m2 polymethylmethacrylate filter (PMMA; Toray) filter and a 0.65-m2 polysulfone (PS; Fresenius) filter. Subjects received 1,000 mg of ceftazidime intravenously prior to the start of a clearance study. The concentration of ceftazidime in multiple plasma …
Peginterferon Alfa-2a In Patients With Chronic Hepatitis C And Cirrhosis, E. Jenny Heathcote, Mitchell L. Shiffman, W. Graham E. Cooksley, Geoffrey M. Dusheiko, Samuel S. Lee, Luis Balart, Robert Reindollar, Rajender K. Reddy, Teresa L. Wright, Amy Lin, Joseph Hoffman, Jean De Pamphilis
Peginterferon Alfa-2a In Patients With Chronic Hepatitis C And Cirrhosis, E. Jenny Heathcote, Mitchell L. Shiffman, W. Graham E. Cooksley, Geoffrey M. Dusheiko, Samuel S. Lee, Luis Balart, Robert Reindollar, Rajender K. Reddy, Teresa L. Wright, Amy Lin, Joseph Hoffman, Jean De Pamphilis
VCU Health Publications
Background
Chronic hepatitis C virus (HCV) infection in patients with cirrhosis is difficult to treat. In patients with chronic hepatitis C but without cirrhosis, once-weekly administration of interferon modified by the attachment of a 40-kd branched-chain polyethylene glycol moiety (peginterferon alfa-2a) is more efficacious than a regimen of unmodified interferon. We examined the efficacy and safety of peginterferon alfa-2a in patients with HCV-related cirrhosis or bridging fibrosis.
Methods
We randomly assigned 271 patients with cirrhosis or bridging fibrosis to receive subcutaneous treatment with 3 million units of interferon alfa-2a three times weekly (88 patients), 90 µg of peginterferon alfa-2a once …
Adult Daycare: Sharing The Caring, Having A Life, Lory Phillippo Osorio
Adult Daycare: Sharing The Caring, Having A Life, Lory Phillippo Osorio
Case Studies from Age in Action
Objectives
1. Demonstrate the role of adult daycare in community-based services for older adults.
2. Illustrate the diversity of services provided in adult daycare/day health care centers in Virginia.
3. Encourage public policy and funding to expand quality adult daycare in the Commonwealth.
The Aging Woman And Hiv/Aids: Increasing Risk And Incidence, Loretta Brush Normile
The Aging Woman And Hiv/Aids: Increasing Risk And Incidence, Loretta Brush Normile
Case Studies from Age in Action
Educational Objectives
1. Discuss the increasing incidence of HIV in the aging population.
2. Describe the ways HIV affects the aging person.
3. Identify implications for HIV education and risk assessment of the older population.
Pace: Program Of All-Inclusive Care Of The Elderly, A. Leigh Peyton, Wendy Boggs, Bill Miller, Nancy Allan
Pace: Program Of All-Inclusive Care Of The Elderly, A. Leigh Peyton, Wendy Boggs, Bill Miller, Nancy Allan
Case Studies from Age in Action
Educational Objectives
1. To describe the origin of PACE.
2. To identify essential services provided by the PACE model.
Aging With Cerebral Palsy: A Consumer’S Perspective, Bryan K. Lacy
Aging With Cerebral Palsy: A Consumer’S Perspective, Bryan K. Lacy
Case Studies from Age in Action
Educational Objectives
1. To illustrate the necessity of an holistic approach to addressing the changing health care needs of adults with Cerebral Palsy.
2. To show the necessity of dealing honestly and creatively with the intimacy/sexuality concerns of older adults with Cerebral Palsy.