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The Interplay Of Defense Mechanisms Against Infectious Diseases, Quentin N. Myrvik
The Interplay Of Defense Mechanisms Against Infectious Diseases, Quentin N. Myrvik
MCV/Q, Medical College of Virginia Quarterly
The total complex of immune expression is an interplay between nonspecific antimicrobial humoral systems plus specific antibodies and accessory factors. These systems are backstopped by the phagocytic functions of PMNs. If these fail, mononuclear phagocytes respond as a second line of defense to carry out chronic engagements. In addition to a direct activation process by "substrate," macrophages may be activated and mobilized by a lymphocyte-mediated immunologic reaction which probably involves either a "lymphotoxin" and/or a specific antibody cytophilic for macrophages. Immunologically activated lymphocytes appear to be the primary effector cells of anti-tissue (transplantation) cellular immunity, whereas immunologically activated macrophages appear …
Cellular Rejection, James S. Wolf
Cellular Rejection, James S. Wolf
MCV/Q, Medical College of Virginia Quarterly
Mounting experimental data suggest that the homograft reaction is intimately related to the small lymphocyte. It is evident that both the afferent and efferent arcs of transplant immunity are dependent upon the intactness of the lymphoid system. The lymphocyte has the ability to recognize the foreign antigen, is involved in the activity of cell-bound antibodies, and may be involved in the inductive processes leading to antibody formation.