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Genomewide Association Study Of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors In Model Organisms, Amy E. Adkins, Laura M. Hack, Tim B. Bigdeli, Vernell S. Williamson, G. Omari Mcmichael, Mohammed Mamdani, Alexis C. Edwards, Fazil Aliev, Robin F. Chan, Poonam Bhandari, Richard C. Raabe, Joseph T. Alaimo, Ginamari G. Blackwell, Arden Moscati, Ryan S. Poland, Benjamin Rood, Diana G. Patterson, Dermot Walsh, Collaborative Study Of The Genetics Of Alcoholism Consortium, John B. Whitfield, Gu Zhu, Grant W. Montgomery, Anjali K. Henders, Nicholas G. Martin, Andrew C. Heath, Pamela A.F. Madden, Josef Frank, Monika Ridinger, Norbert Wodarz, Michael Soyka, Peter Zill, Marcus Ising, Markus M. Nöthen, Falk Kiefer, Marcella Rietschel, The German Study Of The Genetics Of Addiction Consortium, Joel Gelernter, Richard Sherva, Ryan Koesterer, Laura Almasy, Hongyu Zhao, Henry R. Kranzler, Lindsay A. Farrer, Brion S. Maher, Carol A. Prescott, Danielle M. Dick, Silviu A. Bacanu, Laura D. Mathies, Andrew G. Davies, Vladimir I. Vladimirov, Mike Grotewiel, M. Scott Bowers, Jill C. Bettinger, Bradley T. Webb, Michael F. Miles, Kenneth S. Kendler, Brien P. Riley

Psychiatry Publications

Background

Alcohol dependence (AD) shows evidence for genetic liability, but genes influencing risk remain largely unidentified.

Methods

We conducted a genomewide association study in 706 related AD cases and 1,748 unscreened population controls from Ireland. We sought replication in 15,496 samples of European descent. We used model organisms (MOs) to assess the role of orthologous genes in ethanol (EtOH)-response behaviors. We tested 1 primate-specific gene for expression differences in case/control postmortem brain tissue.

Results

We detected significant association in COL6A3 and suggestive association in 2 previously implicated loci, KLF12 and RYR3. None of these signals are significant in replication. …