Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Endogenous Bdnf Augments Nmda Receptor Phosphorylation In The Spinal Cord Via Plcγ, Pkc, And Pi3k/Akt Pathways During Colitis, Miao Liu, Jarren C. Kay, Shanwei Shen, Li-Ya Qiao
Endogenous Bdnf Augments Nmda Receptor Phosphorylation In The Spinal Cord Via Plcγ, Pkc, And Pi3k/Akt Pathways During Colitis, Miao Liu, Jarren C. Kay, Shanwei Shen, Li-Ya Qiao
Physiology and Biophysics Publications
Background
Spinal central sensitization is an important process in the generation and maintenance of visceral hypersensitivity. The release of brain-derived neurotrophic factor (BDNF) from the primary afferent neurons to the spinal cord contributes to spinal neuronal plasticity and increases neuronal activity and synaptic efficacy. The N-Methyl-D-aspartic acid (NMDA) receptor possesses ion channel properties, and its activity is modulated by phosphorylation of its subunits including the NMDA receptor 1 (NR1).
Methods
Colonic inflammation was induced by a single dose of intracolonic instillation of tri-nitrobenzene sulfonic acid (TNBS). NR1 phosphorylation by BDNF in vivo and in culture was examined by western …