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A Network Thermodynamic Approach To Compartmental Analysis: Na+ Transients In Frog Skin, D. C. Mikulecky, E. G. Huf, S. R. Thomas
A Network Thermodynamic Approach To Compartmental Analysis: Na+ Transients In Frog Skin, D. C. Mikulecky, E. G. Huf, S. R. Thomas
Physiology and Biophysics Publications
We introduce a general network thermodynamic method for compartmental analysis which uses a compartmental model of sodium flows through frog skin as an illustrative example (Huf and Howell, 1974a). We use network thermodynamics (Mikulecky et al., 1977b) to formulate the problem, and a circuit simulation program (ASTEC 2, SPICE2, or PCAP) for computation. In this way, the compartment concentrations and net fluxes between compartments are readily obtained for a set of experimental conditions involving a square-wave pulse of labeled sodium at the outer surface of the skin. Qualitative features of the influx at the outer surface correlate very well with …
A Network Thermodynamic Two-Port Element To Represent The Coupled Flow Of Salt And Current. Improved Alternative For The Equivalent Circuit, D. C. Mikulecky
A Network Thermodynamic Two-Port Element To Represent The Coupled Flow Of Salt And Current. Improved Alternative For The Equivalent Circuit, D. C. Mikulecky
Physiology and Biophysics Publications
A two-port for coupled salt and current flow is created by using the network thermodynamic approach in the same manner as that for coupled solute and volume flow (Mikulecky et al., 1977b; Mikulecky, 1977). This electrochemical two-port has distinct advantages over the equivalent circuit representation and overcomes difficulties pointed out by Finkelstein and Mauro (1963). The electrochemical two-port is used to produce a schematic diagram of the coupled flows through a tissue. The network is superimposable on the tissue morphology and preserves the physical qualities of the flows and forces in each part of an organized structure (e.g., an epithelium). …