Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Epigenetic Histone Acetylation And Bdnf Dysregulation In The Hippocampus Of Rats Exposed To Repeated, Low-Dose Diisopropylfluorophosphate, Laxmikant Deshpande
Epigenetic Histone Acetylation And Bdnf Dysregulation In The Hippocampus Of Rats Exposed To Repeated, Low-Dose Diisopropylfluorophosphate, Laxmikant Deshpande
Neurology Publications
Aims: Deployment-related exposures to organophosphate (OP) compounds are implicated for Gulf War Illness (GWI) development in First GW veterans. However, reasons for the persistence of GWI are not fully understood. Epigenetic modifications to chromatin are regulatory mechanisms that can adaptively or maladaptively respond to external stimuli. These include DNA methylation and histone acetylation. DNA methylation changes have been reported in GWI but the role of histone acetylation in GWI has been less explored, despite its importance as an epigenetic mechanism for neurological disorders.
Main methods: Male Sprague-Dawley rats were exposed to OP diisopropyl fluorophosphate (DFP, 0.5 mg/kg s.c., 5-d) and …